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FLASH GENE
Symbol SPECC1L contributors: mct - updated : 26-10-2011
HGNC name sperm antigen with calponin homology and coiled-coil domains 1-like
HGNC id 29022
DNA
TYPE functioning gene
STRUCTURE 146.92 kb     17 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
17 - 6795 123 1117 - 2011 21325884
16 - 6691 123 1117 - 2011 21325884
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal (AAs 1351)
  • central coiled-coil (AAs 351851), specifically bound by TTK
  • C-terminal (AAs 8511,117) segments, with calponin homology domain (CH), important for the association with actin filaments
  • either through direct binding of SPECC1L to actin or via association
    with other actin binding proteins
    HOMOLOGY
    intraspecies homolog to CENPE
    Homologene
    FAMILY
  • cytospin-A family
  • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,intermed filament
    text
  • localizes to a part of the actin filament network during interphase
  • localized to the mitotic spindle during mitosis and to the cytokinetic furrow at an early stage and remained there throughout cell division suggesting a role for the protein in cytokinesis
  • basic FUNCTION
  • required for proper actin organization during
  • mitosis
  • functions to position and stabilize the mitotic
  • spindle
  • its function may be independent of anillin,
  • but require interaction with other cytokinesis components such as actin, myosin or the ezrin, radixin, moesin (ERM) protein family
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with TTK
  • interaction with anillin could explain the
  • complexity of effects we observed with SPECC1L reduction
    in cells
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) OBLFC1
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS