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FLASH GENE
Symbol SPAG9 contributors: mct - updated : 29-05- 201
HGNC name sperm associated antigen 9
HGNC id 14524
Location 17q21.33      Physical location : 49.039.535 - 49.198.226
Synonym name
  • JUN-interacting leucine zipper protein
  • sunday dryver Drosophila, homolog of 1
  • proliferation-inducing gene 6
  • sperm specific protein
  • JNK/SAPK-associated protein
  • c-Jun NH2-terminal kinase-associated leucine zipper protein
  • Max-binding protein
  • HLC-4 protein
  • lung cancer oncogene 4
  • proliferation-inducing gene 6
  • cancer/testis antigen 89
  • Synonym symbol(s) HSS, SYD1, FLJ13450, FLJ14006, FLJ34602, HLC4, JLP, KIAA0516, PHET, PIG6, JIP4, MGC14967, MGC74461, MGC117291,FLJ26141, CT89, MAPK8IP4
    DNA
    TYPE functioning gene
    STRUCTURE 158.70 kb     30 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    motif repetitive sequence   other
    text structure and other palindromic sequences
    MAPPING cloned Y linked N status provisional
    Physical map
    ITGA3 17q22-q23 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) PDK2 17q21.3 pyruvate dehydrogenase kinase, isoenzyme 2 LOC201191 17q21.33 hypothetical protein LOC201191 PPP1R9B 17q21-q22 protein phosphatase 1, regulatory subunit 9B, spinophilin SGCA 17q21 sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) HILS1 17q21.33 spermatid-specific linker histone H1-like protein COL1A1 17q21.31-q22.15 collagen, type I, alpha 1 FLJ33318 17q21.33 hypothetical protein FLJ33318 XYLT2 17q21.3-17q22 xylosyltransferase II MRPL27 17q21.3-q22 mitochondrial ribosomal protein L27 FLJ31364 PRO1855 17q21.33 hypothetical protein PRO1855 FLJ20920 17q21.33 hypothetical protein FLJ20920 MRPS21P9 17q21 mitochondrial ribosomal protein S21 pseudogene 9 CHAD 17q21.33 chondroadherin FLJ11164 17q21.33 hypothetical protein FLJ11164 DKFZp434N1415 17q21.33 Mycbp-associated protein EPN3 17q24.1 epsin 3 FLJ21347 17q21.33 hypothetical protein FLJ21347 LOC253962 17q21.33 hypothetical protein LOC253962 CACNA1G 17q22 calcium channel, voltage-dependent, alpha 1G subunit ABCC3 17q21.3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 MGC15396 17q21.33 hypothetical protein MGC15396 LUC7A 17q21 cisplatin resistance-associated overexpressed protein OA48-18 17q21.33 acid-inducible phosphoprotein FLJ20694 17q21.33 hypothetical protein FLJ20694 LOC390801 17 similar to S100 calcium-binding protein A10; S100 calcium-binding protein A10 (annexin II ligand, calpactin I, light polypeptide (p11)); annexin II ligand, calpactin I, light polypeptide WFIKKNRP 17q21.33 WFIKKN-related protein LOC390802 17 similar to ribosomal protein L5; 60S ribosomal protein L5 TOB1 17q21 transducer of ERBB2, 1 SPAG9 17q21.31 sperm associated antigen 9 NME1 17q21.31 non-metastatic cells 1, protein (NM23A) expressed in NME2 17q21.31 non-metastatic cells 2, protein (NM23B) expressed in MBTD1 17q24.1 mbt domain containing 1 CGI-48 17q21.33 CGI-48 protein LOC388401 17 similar to ribosomal protein L7 CA10 17q24 carbonic anhydrase X
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    30 - 8273 - 1321 - 2009 1635647
    29 - 8231 - 1307 - 2009 1635647
    - - 7940 - 1177 - 2009 1635647
    - - 8243 - 1311 - 2009 1635647
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immuneactivated B lymphocyte Mus musculus
    Reproductivespermatid
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal extracellular leucine zipper motif and multiple repeats (five direct, three mirror)
  • three unique palindromic motifs
  • transmembrane helical domain
  • coiled coil, leucine zipper domain, essential for dimerization and proper localization
  • C terminal cytoplasmic domain
  • HOMOLOGY
    interspecies homolog to Drosophila sunday driver
    intraspecies homolog to MAPK8IP1
    homolog to MAPK8IP3
    Homologene
    FAMILY
  • JNK-interacting protein family
  • CATEGORY antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    basic FUNCTION
  • mediating the axonal transport of at least 1 class of vesicles by interacting directly with kinesin light chain
  • sperm-associated JNK-binding protein, having a functional role in sperm-egg fusion
  • involvement of SPAG9 mediated signal transduction pathways in reproductive processes
  • its expression may play a role in cellular growth and thyroid carcinogenesis
  • may have a role in tumor development and early spread and thus could serve as a novel target for early detection and for cancer immunotherapy
  • acts together with MAPK8IP3 to promote presynaptic assembly
  • novel role of a scaffolding protein SPAG9 in the regulation of surface CD40 expression and fine-tuning of dendritic cells function
  • MAPK8IP3 and SPAG9 are critical and functionally redundant in cytokinesis and control ARF6 localization to the midbody by forming a tripartite complex of MAPK8IP3/SPAG9, active ARF6, and kinesin-1
  • novel role of SPAG9 scaffold protein in the bridging of CD40LG-triggered CD40 internalization and CD40-dependent signaling in splenic B lymphocytes
  • MAPK8IP3, SPAG9 are positive regulators of kinesin-1-dependent axonal transport, which prevents neuronal degeneration
  • SPAG9 and MAPK8IP3 play critical roles in kinesin-1-dependent axonal transport, which prevents brain neuronal degeneration
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with KLC1 as a binding partner for the second leucine zipper domain (involves leucine zipper-like domains and support the role of motor proteins in the spatial regulation of signaling modules)
  • novel target protein of the active form of ARF6
  • MAPK8IP3, SPAG9 which might be paralogous to each other, are critical and functionally redundant in cytokinesis and control ARF6 localization to the midbody by forming a tripartite complex of MAPK8IP3/SPAG9, active ARF6, and kinesin-1
  • PLK1 binding to SPAG9 was found in G2 phase and mitosis, and PLK1 binding was self-primed by PLK1 phosphorylation of SPAG9
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • new type of endometrial cancer markers for early detection, diagnosis and treatment
  • Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    potential of SPAG9 as a biomarker and immunotherapeutic target for early treatment of chronic myeloid leukemia -chronic phase patients
    cancerendocrinethyroid
    diagnostic biomarker as well as a possible therapeutic target in thyroid cancer treatment
    ANIMAL & CELL MODELS