Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SPAG8 contributors: mct - updated : 25-10-2010
HGNC name sperm associated antigen 8
HGNC id 14105
Location 9p13.3      Physical location : 35.807.783 - 35.812.259
Synonym name sperm membrane protein 1
Synonym symbol(s) BS-84, HSD1, SMP1, SMP-1, SPAG3
DNA
TYPE functioning gene
STRUCTURE 4.49 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
FANCG 9p13 Fanconi anemia, complementation group G PIGO 9p13.2 phosphatidylinositol glycan, class O STOML2 9p13 stomatin (EPB72)-like 2 FLJ11560 9p13.2 hypothetical protein FLJ11560 LOC347241 9p13.2 similar to Zinc finger protein 492 UNC13B 9p12-p11 unc-13 homolog B (C. elegans) PRO0038 9p13.2 PRO0038 protein LOC389717 9 hypothetical gene supported by BC035229; BC047452 RUSC2 9p13.2 RUN and SH3 domain containing 2 LOC138729 9p13.2 hypothetical gene LOC138729 TESK1 9p13 testis-specific kinase 1 CD72 9p13.1 CD72 antigen SIT 9p13-p12 CD72 antigen MGC31967 9p13.2 hypothetical protein MGC31967 FLJ14642 9p13.2 hypothetical protein FLJ14642 CA9 9p13-p12 carbonic anhydrase IX TPM2 9p13.2-p13.1 tropomyosin 2 (beta) TLN1 9p13 talin 1 CREB3 9p13.2 cAMP responsive element binding protein 3 (luman) GBA2 9p13.3-p11.2 glucosidase, beta (bile acid) 2 KIAA0258 9pter-p22.1 KIAA0258 protein NPR2 9p21-p12 natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B) SPAG8 9p13-p12 sperm associated antigen 8 HINT2 9p11.2 histidine triad nucleotide binding protein 2 LOC392307 9 similar to RIKEN cDNA 4930412F15 gene NGX6 9p13.1 nasopharyngeal carcinoma related protein LOC389718 9 LOC389718 LOC392308 9 similar to Olfactory receptor 70 LOC392309 9 similar to Olfactory receptor 13J1 LOC392310 9 similar to Phosphoglycerate mutase 1 (Phosphoglycerate mutase isozyme B) (PGAM-B) (BPG-dependent PGAM 1) OR2S2 9p13.3-p13.1 olfactory receptor, family 2, subfamily S, member 2 LOC389719 9 hypothetical gene supported by M24070; NM_004559 LOC392311 9 similar to seven transmembrane helix receptor OR13C7P 9 olfactory receptor, family 13, subfamily C, member 7 pseudogene LOC392313 9 similar to olfactory receptor RECK 9p13-p12 reversion-inducing-cysteine-rich protein with kazal motifs C9orf19 9p12-p13 chromosome 9 open reading frame 19 CCIN 9p13-p12 calicin CLTA 9p13-p12 clathrin, light polypeptide (Lca) GNE 9p13-p12 clathrin, light polypeptide (Lca) LOC392314 9 similar to high mobility group protein homolog HMG4 RNF38 9p13-p12 ring finger protein 38
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 1715 - 485 - 2010 20488182
- splicing initiation site 2140 - 426 testis 1999 10500252
  • truncated
  • deletion of the 5'end
  • 8 - 2010 53.5 501 - 2010 20488182
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  predominantly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivesperm cell
    Reproductivespermatid
    Reproductivespermatocyte
    cell lineage germ cells (acrosomal region of mature spermatozoa)
    cell lines
    fluid/secretion sperm
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • type 2 membrane protein
  • concentrated at the microtubule-organizing center (MTOC) during prophase
  • expression appeared to be concentrated in the region of the acrosome and the middle piece of the tail in mature spermatozoa
  • basic FUNCTION
  • testis-specific protein produced during male germ cell differentiation
  • might play a role in cell division during spermatogenesis
  • functions in a germ cell type- and stage-specific manner during spermatogenesis
  • regulator that enhances the transcriptional activation of FHL5-mediated CREM
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • testis-specific component produced during male germ cell differentiation
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction between SPAG8 and RANBP9 may be involved in the process of male germ cell differentiation
  • interacts with tubulins and thereby may modulate microtubule assembly and/or activity
  • interacts with FHL5, which suggests that SPAG8 could be associated with FHL5 during spermatogenesis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS