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FLASH GENE
Symbol SPAG8 contributors: mct - updated : 25-10-2010
HGNC name sperm associated antigen 8
HGNC id 14105
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 1715 - 485 - 2010 20488182
- splicing initiation site 2140 - 426 testis 1999 10500252
  • truncated
  • deletion of the 5'end
  • 8 - 2010 53.5 501 - 2010 20488182
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  predominantly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivesperm cell
    Reproductivespermatid
    Reproductivespermatocyte
    cell lineage germ cells (acrosomal region of mature spermatozoa)
    cell lines
    fluid/secretion sperm
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • type 2 membrane protein
  • concentrated at the microtubule-organizing center (MTOC) during prophase
  • expression appeared to be concentrated in the region of the acrosome and the middle piece of the tail in mature spermatozoa
  • basic FUNCTION
  • testis-specific protein produced during male germ cell differentiation
  • might play a role in cell division during spermatogenesis
  • functions in a germ cell type- and stage-specific manner during spermatogenesis
  • regulator that enhances the transcriptional activation of FHL5-mediated CREM
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • testis-specific component produced during male germ cell differentiation
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction between SPAG8 and RANBP9 may be involved in the process of male germ cell differentiation
  • interacts with tubulins and thereby may modulate microtubule assembly and/or activity
  • interacts with FHL5, which suggests that SPAG8 could be associated with FHL5 during spermatogenesis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS