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FLASH GENE
Symbol SPAG6 contributors: mct - updated : 23-03-2007
HGNC name sperm associated antigen 6
HGNC id 11215
Location 10p12-p11.2      Physical location : 22.634.398 - 22.706.538
Synonym name
  • axoneme central apparatus protein
  • sperm flagellar protein
  • Synonym symbol(s) RSA1, PFIC, MGC26276, Repro-SA-1, pf16
    DNA
    TYPE functioning gene
    STRUCTURE 72.00 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site
    text structure absence of a TATA box, and putative binding sites for several factors implicated in spermatogenesis (CREB/CREM, SOX17 and SPZ1) as well as ciliogenesis (FOXJ1
    MAPPING cloned Y linked   status provisional
    Physical map
    LOC340893 10p13 similar to protein of unknown function MRC1 10p13 mannose receptor, C type 1 SLC39A12 10p13 solute carrier family 39 (zinc transporter), member 12 CACNB2 10p12 calcium channel, voltage-dependent, beta 2 subunit NOPD1 10p13 nucleolar protein (NOL1/NOP2/sun) and PUA domains 1 ARL8 10p13 ADP-ribosylation factor-like 8 LOC389942 10 similar to Programmed cell death protein 8, mitochondrial precursor (Apoptosis-inducing factor) LOC387635 10 similar to ubiquitin-conjugating enzyme E2 variant 1 isoform a; DNA-binding protein LOC340895 10p12.33 similar to apical early endosomal glycoprotein precursor LOC387636 10 LOC387636 PLXDC2 10p12.33 plexin domain containing 2 LOC220998 10p12.33 similar to Protein C21orf59 NEBL 10p12 similar to Protein C21orf59 LOC387637 10 similar to eukaryotic initiation factor 4B LOC387638 10 LOC387638 LOC387639 10 LOC387639 LOC219689 10p12.33 similar to putative RNA methyltransferase LOC387640 10 similar to RIKEN cDNA E130012A19 MLLT10 10p12 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 DNAJC1 10p12.31 DnaJ (Hsp40) homolog, subfamily C, member 1 LOC340900 10p12.32 similar to Hypothetical protein FLJ10213 LOC338098 10p12 proteasome activator subunit 2 pseudogene LOC389943 10 similar to ribosomal protein L31 BMI1 10p13 B lymphoma MO-MLV insertion region (mouse) C10orf8 10pter-q22.1 chromosome 10 open reading frame 8 SPAG6 10p12-p11.2 sperm associated antigen 6 PIP5K2A 10p11.23 phosphatidylinositol-4-phosphate 5-kinase, type II, alpha FLJ32827 PILB 10p12 phosphatidylinositol-4-phosphate 5-kinase, type II, alpha LOC143371 10p12.31 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta pseudogene PTF1A 10p12.31 pancreas specific transcription factor, 1a LOC387642 10 similar to RIKEN cDNA 4921522E24 MGC46732 LOC220213 10p12.31 hypothetical protein LOC220213 DKFZP761L0424 ARHGAP21 10p12.31 Rho GTPase activating protein 21 PRTFDC1 10p12.31 phosphoribosyl transferase domain containing 1 MGC26778 FLJ22002 10p12.31 hypothetical protein FLJ22002 GPR158 10p12.31 G protein-coupled receptor 158 MYO3A 10p11.1 myosin IIIA GAD2 10p11.23 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) APBB1IP 10p12.2 amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein LOC387643 10 similar to amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein; proline-rich protein 73; Rap1-interacting adaptor molecule TPT 10p12.2-p12.1 trans-prenyltransferase SSH3BP1 10p11.2 spectrin SH3 domain binding protein 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 2630 - 509 - Ficarro
    - - 2463 - 458 - Ficarro
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Endocrineparathyroid   highly
    Reproductivemale systemtestis  predominantly Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    eight contigous Armadillo repeats
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY structural protein , antigen
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    basic FUNCTION
  • mediating protein-protein interaction
  • essential for sperm flagellar motility and is important for the maintenance of the structural integrity of mature sperm
  • plays an important role in sperm flagellar function
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS