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FLASH GENE
Symbol SPAG6 contributors: mct - updated : 25-05-2020
HGNC name sperm associated antigen 6
HGNC id 11215
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 2568 - 509 - 2017 28393201
10 - 2422 - 458 - 2017 28393201
11 - 2799 - 484 - 2017 28393201
12 - 2923 - 484 - 2017 28393201
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineparathyroid   highly
Nervousbrain   highly Homo sapiens
 spinal cord     Homo sapiens
Reproductivefemale systemovary    Homo sapiens
 male systemtestis  predominantly Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivesperm cell Homo sapiens
Reproductivespermatocyte Homo sapiens
Reproductivespermatogonia Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
eight contigous Armadillo repeats
HOMOLOGY
interspecies ortholog to Chlamydomonas reinhardtii PF16
Homologene
FAMILY cancer-testis antigen family
CATEGORY structural protein , antigen
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytoskeleton,microtubule
intracellular,nucleus
basic FUNCTION
  • mediating protein-protein interaction
  • essential for sperm flagellar motility and is important for the maintenance of the structural integrity of mature sperm
  • axoneme central apparatus protein, is essential for function of ependymal cell cilia and sperm flagella
  • SPAG6 not only regulates cilia/flagellar motility, but that in its absence, ciliogenesis, axoneme orientation, and tracheal epithelial cell polarity are altered
  • might have a role in malignant myeloid hematologic cell proliferation and apoptosis by regulating caspase proteins and TP53
  • plays an important role in sperm flagellar function
  • is crucial for sperm motility
  • likely controlled neuronal migration as well as neurite branching and elongation
  • selectively increased expression of acetylated tubulin, a microtubule stability marker
  • new roles for SPAG6 in modulation of cell morphology, proliferation, migration, and ciliogenesis
  • plays an essential role in the process of neuronal proliferation and differentiation
  • SPAG6 and L1TD1 are tumor-specifically methylated in non-small cell lung cancer (NSCLC) and DNA methylation is involved in the transcriptional regulation of these genes
  • potential role of SPAG6 and SPAG16 stabilizing the cytoplasmic microtubules of eukaryotic cells
  • SPAG6 gene regulates tumor cell proliferation, apoptosis, invasion, and metastasis
  • likely SPAG6 gene could affect hearing by regulating the expression of SLC26A5 gene
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SPAG6 may regulate apoptosis in SCN4A through the TNFSF10 signal pathway
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in non-small cell lung cancer (NSCLC)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    SPAG6 could be a potential therapeutic target in myelodysplastic syndromes
    ANIMAL & CELL MODELS