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FLASH GENE
Symbol SOS2 contributors: mct - updated : 03-09-2019
HGNC name son of sevenless homolog 2 (Drosophila)
HGNC id 11188
Corresponding disease
NS9 Noonan syndrome 9
Location 14q21.3      Physical location : 50.583.846 - 50.698.099
Synonym name guanine nucleotide exchange factor
Synonym symbol(s) FLJ25596, NS9
DNA
TYPE functioning gene
STRUCTURE 114.45 kb     23 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Physical map
ATP5GP2 14q21.3 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9) pseudogene 2 LOC387988 14 hypothetical gene supported by BC015974 RPS29 14q13.3-q21.1 ribosomal protein S29 PPIL5 14q21.3 peptidylprolyl isomerase (cyclophilin) like 5 ARHQP 14 ras homolog gene family, member Q pseudogene RPL36AL 14q21 ribosomal protein L36a-like MGAT2 14q21 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase C14orf104 14q21.3 chromosome 14 open reading frame 104 POLE2 14q21-q22 polymerase (DNA directed), epsilon 2 (p59 subunit) STK16P 14 serine/threonine kinase 16 pseudogene KLHDC1 14q21.3 kelch domain containing 1 KLHDC2 14q21.3 kelch domain containing 2 SDCCAG1 14q22 serologically defined colon cancer antigen 1 ARF6 7q22.1 ADP-ribosylation factor 6 LOC283551 14q22.1 hypothetical protein LOC283551 PDLIM1P 14 PDZ and LIM domain 1 pseudogene RPS15AP2 14 ribosomal protein S15a pseudogene 2 LOC196913 14q22.1 hypothetical protein LOC196913 C14orf138 14q22.1 chromosome 14 open reading frame 138 SOS2 14q22 son of sevenless homolog 2 (Drosophila) C14orf160 14q22.1 chromosome 14 open reading frame 160 ATP5S 14q21.3 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit s (factor B) CDKL1 14q22.1 cyclin-dependent kinase-like 1 (CDC2-related kinase) MAP4K5 14q13.2-q21 mitogen-activated protein kinase kinase kinase kinase 5 SPG3A 14q21.3 spastic paraplegia 3A (autosomal dominant) SNRPGP 14 small nuclear ribonucleoprotein polypeptide G pseudogene SAV1 14q13-q23 salvador homolog 1 (Drosophila) ZNF405P 14 zinc finger protein 405 pseudogene NIN 14q21.3-q22 ninein (GSK3B interacting protein)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
23 - 5508 - 1332 - 1995 7629138
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinethyroid   highly
Hearing/Equilibriumear   highly
Lymphoid/Immunelymph node   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a DH (dbl-homology) domain
  • a N-terminal RAS-GEF domain
  • a PH domain
  • a RAS-GEF domain
  • HOMOLOGY
    interspecies homolog to Drosophila son of sevenless,2
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,chromatin/chromosome,nucleosome
    basic FUNCTION
  • promoting the exchange of RAS-bound GDP by GTP
  • SOS2 is dispensable for NMDA-induced Erk activation and long-term potentiation (LTP) induction
  • SOS1 and SOS2 are ubiquitously expressed, universal Ras guanine nucleotide exchange factors (Ras-GEFs) acting in multiple signal transduction pathways activated by upstream cellular kinases
  • functional redundancy between SOS1 and SOS2 for homeostasis and survival of the full organism and for development and maturation of T and B lymphocytes
  • SOS1 and SOS2 are ubiquitously expressed Ras-guanine exchange factors involved in Erk-MAP kinase pathway activation
  • essential role of SSOS1, SOS2 proteins in cellular proliferation and migration
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SOS2-dependent PI3K signaling mediates mutant KRAS-driven transformation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) NS9
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS