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FLASH GENE
Symbol SOS2 contributors: mct - updated : 03-09-2019
HGNC name son of sevenless homolog 2 (Drosophila)
HGNC id 11188
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinethyroid   highly
Hearing/Equilibriumear   highly
Lymphoid/Immunelymph node   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a DH (dbl-homology) domain
  • a N-terminal RAS-GEF domain
  • a PH domain
  • a RAS-GEF domain
  • HOMOLOGY
    interspecies homolog to Drosophila son of sevenless,2
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,chromatin/chromosome,nucleosome
    basic FUNCTION
  • promoting the exchange of RAS-bound GDP by GTP
  • SOS2 is dispensable for NMDA-induced Erk activation and long-term potentiation (LTP) induction
  • SOS1 and SOS2 are ubiquitously expressed, universal Ras guanine nucleotide exchange factors (Ras-GEFs) acting in multiple signal transduction pathways activated by upstream cellular kinases
  • functional redundancy between SOS1 and SOS2 for homeostasis and survival of the full organism and for development and maturation of T and B lymphocytes
  • SOS1 and SOS2 are ubiquitously expressed Ras-guanine exchange factors involved in Erk-MAP kinase pathway activation
  • essential role of SSOS1, SOS2 proteins in cellular proliferation and migration
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SOS2-dependent PI3K signaling mediates mutant KRAS-driven transformation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) NS9
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS