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FLASH GENE
Symbol SORBS2 contributors: mct - updated : 17-07-2017
HGNC name sorbin and SH3 domain containing 2
HGNC id 24098
Location 4q35.1      Physical location : 186.506.598 - 186.877.870
Synonym name
  • ARG binding protein 2
  • Arg/Abl-interacting protein ArgBP2
  • Synonym symbol(s) KIAA0777, ARGBP2, PRO0618
    DNA
    TYPE functioning gene
    STRUCTURE 371.00 kb     23 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - initiation site 5996 - 1100 - Wang
    - - 4938 - 620 - Wang
    5' end small in frame insertion, large in frame deletion
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumcardiac  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a serine/threonine rich domain
  • several potential Abl phosphorylation sites
  • three C terminal Src homology 3 (SH3) domains
  • a sorbin homologous domain
  • HOMOLOGY
    interspecies ortholog to rattus Argbp2
    Homologene
    FAMILY glycosyl hydrolase 2 family
    CATEGORY adaptor , structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    text
  • stress fibers in epithelial cells
  • Z disks of sarcomeres
  • basic FUNCTION
  • potential link between Abl family kinases and the actin cytoskeleton
  • potential modification of contractile or elastic propertie of cardiac sarcomere
  • adapter protein that plays an important role in actin-dependent processes such as cell adhesion and migration
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ABL1, ABL2 (ARG)
  • FMR1 (RNA target of FMR1)
  • MORC2 enhanced the recruitment of EZH2, which promoted the tri-methylation of H3K27, leading to the transcriptional repression of SORBS2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivestomach
    is a potential therapeutic target for gastric cancer
    ANIMAL & CELL MODELS