Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

SORBS2

contributors: mct - updated : 17-07-2017

HGNC name	sorbin and SH3 domain containing 2
HGNC id	24098

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 2 - initiation site 5996 - 1100 - Wang variant 1 - - 4938 - 620 - Wang 5' end small in frame insertion, large in frame deletion

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum cardiac

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a serine/threonine rich domain
	several potential Abl phosphorylation sites
	three C terminal Src homology 3 (SH3) domains
	a sorbin homologous domain

HOMOLOGY

interspecies

ortholog to rattus Argbp2

Homologene

FAMILY

glycosyl hydrolase 2 family

CATEGORY

adaptor , structural protein

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton
text	stress fibers in epithelial cells
	Z disks of sarcomeres

basic FUNCTION	potential link between Abl family kinases and the actin cytoskeleton
	potential modification of contractile or elastic propertie of cardiac sarcomere
	adapter protein that plays an important role in actin-dependent processes such as cell adhesion and migration

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	ABL1, ABL2 (ARG)
	FMR1 (RNA target of FMR1)
	MORC2 enhanced the recruitment of EZH2, which promoted the tri-methylation of H3K27, leading to the transcriptional repression of SORBS2

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer digestive stomach is a potential therapeutic target for gastric cancer

ANIMAL & CELL MODELS