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FLASH GENE
Symbol SOCS2 contributors: mct - updated : 08-02-2016
HGNC name suppressor of cytokine signaling 2
HGNC id 19382
Location 12q21.33      Physical location : 93.963.597 - 93.969.978
Synonym name
  • cytokine inducible SH2-containing protein
  • STAT induced STAT inhibitor-2
  • Synonym symbol(s) STAT12, SSI2, CISH2, CIS2
    DNA
    TYPE functioning gene
    STRUCTURE 6.00 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Physical map
    LUM 12q21.3-q22 lumican DCN 12q13.2 decorin BTG1 12q22 B-cell translocation gene 1, anti-proliferative LOC387872 12 hypothetical gene supported by BC044741 LOC390351 12 similar to 60S ribosomal protein L21 LOC283388 12q22 similar to guanine nucleotide exchange factor (1B384) EEA1 12q21.31 early endosome antigen 1, 162kD LOC341444 12q22 similar to alpha NAC/1.9.2. protein LOC387873 12 LOC387873 NUDT4 12q21 nudix (nucleoside diphosphate linked moiety X)-type motif 4 UBE2N 12q21.33 ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast) MRPL42 12q22 mitochondrial ribosomal protein L42 SOCS2 12q21.3-q23 suppressor of cytokine signaling 2 LOC144483 12q22 similar to Phosphoglycerate mutase 1 (Phosphoglycerate mutase isozyme B) (PGAM-B) (BPG-dependent PGAM 1) CRADD 12q21.33-q23.1 CASP2 and RIPK1 domain containing adaptor with death domain PLXNC1 12q23.3 plexin C1 NY-REN-58 12q22 NY-REN-58 antigen LOC387874 12 hypothetical gene supported by NM_014886 LOC283398 12q22 similar to Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial precursor (Succinyl-CoA synthetase, betaG chain) (SCS-betaG) (GTP-specific succinyl-CoA synthetase beta subunit) KIAA1145 12q22 KIAA1145 protein DAP13 12q23.1 13kDa differentiation-associated protein NR2C1 12q22 nuclear receptor subfamily 2, group C, member 1 FGD6 12q23.1 FYVE, RhoGEF and PH domain containing 6 VEZATIN 12q21.33 FYVE, RhoGEF and PH domain containing 6 LOC387875 12 LOC387875 LOC283412 12q23.1 similar to 60S ribosomal protein L29 (Cell surface heparin binding protein HIP) METAP2 12q22 methionyl aminopeptidase 2 USP44 12q21.33 ubiquitin specific protease 44 NTN4 12q22-q23 netrin 4 SNRPF 12q21.33 small nuclear ribonucleoprotein polypeptide F FLJ40089 12q23.1 hypothetical protein FLJ40089 MGC35366 12q23.1 hypothetical protein MGC35366
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver    
    Endocrineparathyroid   highly
    Reproductivemale systemprostate  highly
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    Connectiveadipose  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Endocrineislet cell (alpha,beta...)
    cell lineage hematopoietic cell lineages
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text placenta, kidney
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • solitary Src homology SH2 domain
  • conserved SOCS-box motif being essential for all inhibitory function
  • a C terminal SOCS, CIS (CH domain) sequence
  • HOMOLOGY
    Homologene
    FAMILY suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family
    CATEGORY regulatory , signaling cytokine
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text localization regulated by cellular conditions (nuclear localization being stimulated by conditions that increased cytoplasmic protein levels)
    basic FUNCTION
  • involved in the interleukin-6 induced receptor phosphorylation and in the negative regulation of cytokine induced STAT factor signaling
  • regulating protein turnover, targeting proteins for proteasome-mediated degradation
  • may acting either as an enhancer or suppressor of growth hormone signaling
  • negative regulator of GH signaling
  • SOCS2 associates with activated FLT3 and negatively regulates the FLT3 signaling pathways
  • CELLULAR PROCESS cell life, proliferation/growth
    protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding and regulating activated insulin-like growth factor receptor 1 (IGF1R)
  • mediating estrogen inhibition of GH1 signaling
  • binding the erythropoietin receptor
  • bind 2 phosphorylated tyrosines on the GH receptor
  • SOCS2 negatively regulates FLT3 signaling by blocking activation of Erk 1/2 and STAT5
  • cell & other
    REGULATION
    induced by EPO,CSF2
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to asthma and atopy
  • to type 2 diabetes
  • Variant & Polymorphism SNP increasing the risk of type 2 diabetes
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    promoting mouse neural development by blocking growth hormone mediated downregulation of neurogenin