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FLASH GENE

Symbol

SOCS2

contributors: mct - updated : 08-02-2016

HGNC name	suppressor of cytokine signaling 2
HGNC id	19382

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	12q21.33      Physical location : 93.963.597 - 93.969.978
Synonym name	cytokine inducible SH2-containing protein
	STAT induced STAT inhibitor-2
Synonym symbol(s)	STAT12, SSI2, CISH2, CIS2

DNA

TYPE	functioning gene
STRUCTURE	6.00 kb     3 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

confirmed

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive liver         Endocrine parathyroid       highly Reproductive male system prostate     highly Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     highly Connective adipose     highly

cells

System Cell Pubmed Species Stage Rna symbol Endocrine islet cell (alpha,beta...)

cell lineage	hematopoietic cell lineages
cell lines
fluid/secretion

at STAGE

physiological period

fetal, pregnancy

Text	placenta, kidney

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	solitary Src homology SH2 domain
	conserved SOCS-box motif being essential for all inhibitory function
	a C terminal SOCS, CIS (CH domain) sequence

HOMOLOGY

Homologene

FAMILY

suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family

CATEGORY

regulatory , signaling cytokine

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus
text	localization regulated by cellular conditions (nuclear localization being stimulated by conditions that increased cytoplasmic protein levels)

basic FUNCTION	involved in the interleukin-6 induced receptor phosphorylation and in the negative regulation of cytokine induced STAT factor signaling
	regulating protein turnover, targeting proteins for proteasome-mediated degradation
	may acting either as an enhancer or suppressor of growth hormone signaling
	negative regulator of GH signaling
	SOCS2 is an ubiquitin ligase for the GHR unveils the molecular basis for its physiological actions
	SOCS2 associates with activated FLT3 and negatively regulates the FLT3 signaling pathways

CELLULAR PROCESS	cell life, proliferation/growth
	protein, degradation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	binding and regulating activated insulin-like growth factor receptor 1 (IGF1R)
	mediating estrogen inhibition of GH1 signaling
	binding the erythropoietin receptor
	bind 2 phosphorylated tyrosines on the GH receptor
	interaction with ELOB/ELOC controls SOCS2 protein turnover and affects its molecular activity
	SOCS2 negatively regulates FLT3 signaling by blocking activation of Erk 1/2 and STAT5
	SOCS2-interacting protein, and binding requires the SOCS2 SH2 domain and EPHA2 activation loop autophosphorylation, which is stimulated by EFNA1 or by phosphotyrosine phosphatase inhibition

cell & other

REGULATION

induced by

EPO,CSF2

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to asthma and atopy to type 2 diabetes

Variant & Polymorphism SNP	increasing the risk of type 2 diabetes

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

promoting mouse neural development by blocking growth hormone mediated downregulation of neurogenin