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FLASH GENE
Symbol SOCS2 contributors: mct - updated : 08-02-2016
HGNC name suppressor of cytokine signaling 2
HGNC id 19382
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • solitary Src homology SH2 domain
  • conserved SOCS-box motif being essential for all inhibitory function
  • a C terminal SOCS, CIS (CH domain) sequence
    • HOMOLOGY
    Homologene
    FAMILY suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family
    CATEGORY regulatory , signaling cytokine
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text localization regulated by cellular conditions (nuclear localization being stimulated by conditions that increased cytoplasmic protein levels)
    basic FUNCTION
  • involved in the interleukin-6 induced receptor phosphorylation and in the negative regulation of cytokine induced STAT factor signaling
  • regulating protein turnover, targeting proteins for proteasome-mediated degradation
  • may acting either as an enhancer or suppressor of growth hormone signaling
  • negative regulator of GH signaling
  • SOCS2 is an ubiquitin ligase for the GHR unveils the molecular basis for its physiological actions
  • SOCS2 associates with activated FLT3 and negatively regulates the FLT3 signaling pathways
    • CELLULAR PROCESS cell life, proliferation/growth
    protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding and regulating activated insulin-like growth factor receptor 1 (IGF1R)
  • mediating estrogen inhibition of GH1 signaling
  • binding the erythropoietin receptor
  • bind 2 phosphorylated tyrosines on the GH receptor
  • interaction with ELOB/ELOC controls SOCS2 protein turnover and affects its molecular activity
  • SOCS2 negatively regulates FLT3 signaling by blocking activation of Erk 1/2 and STAT5
  • SOCS2-interacting protein, and binding requires the SOCS2 SH2 domain and EPHA2 activation loop autophosphorylation, which is stimulated by EFNA1 or by phosphotyrosine phosphatase inhibition
    • cell & other
    REGULATION
    induced by EPO,CSF2
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to asthma and atopy
  • to type 2 diabetes
    • Variant & Polymorphism SNP increasing the risk of type 2 diabetes
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    promoting mouse neural development by blocking growth hormone mediated downregulation of neurogenin