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FLASH GENE

Symbol

SNX15

contributors: - updated : 24-10-2005

HGNC name	sorting nexin 15
HGNC id	14978

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	11q12      Physical location : 64.794.909 - 64.808.042

DNA

TYPE	functioning gene
STRUCTURE	13.00 kb     7 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed SNX15 - - - - 342 - Phillips SNX15A - splicing - - 256 adult brain, liver, placenta Phillips

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen           thymus         Cardiovascular heart         Digestive intestine small intestine       Nervous brain         Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Lymphoid         Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES		globular
STRUCTURE

motifs/domains	N terminal PHOX homology domain
	a C terminal ESP domain
	a MIT domain

mono polymer

homomer , heteromer , polymer

HOMOLOGY

Homologene

FAMILY

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,Golgi
	intracellular,cytoplasm,organelle,endosome

basic FUNCTION

playing a role in the normal trafficking of protein from the plasma membrane to recycling endosome or the trans-Golgi network

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

cellular trafficking transport

text	receptor trafficking

PATHWAY

metabolism

signaling

a component

homo and hetero oligomers with SNX1, SNX2, SNX3, SNX4

INTERACTION

DNA

RNA

small molecule

protein	platelets derived growth factor receptors (PGDFRA, PDGFRB)
	interacting with ESCRT-III proteins

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS