basic FUNCTION
| actin-dependent regulator of chromatin structure, generating and interconverting multiple nucleosomes states |
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regulating the expression of CDKN1A and activating RB1 by inducing its hypophosphorylation through up-regulation of the CDKN1A |
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during mitosis, phosphorylated and excluded from the condensed chromosomes |
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controlling cellular proliferation and senescence by modulating the RB1 pathway via multiple mechanisms |
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inducing Z-DNA formation and promoting a transition from a transient and partial remodeling to a more extensive disruption of the canonical nucleosomal structure |
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facilitates REST repression by increasing the interaction between REST and chromatin |
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may be required for embryonic stem cells growth perhaps through functions in addition to transcriptional regulation |
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role in the regulation of thymocyte cell proliferation and survival |
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critical function of Brg-1 in regulating the recruitment of Sp1, Sp3, AP-2, and polymerase II to the MMP-2 promoter |
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plays significant roles in enhancing LXR/RXR-mediated transcription of ABCA1 via the promoter DR-4 element |
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has an apical role in cytokine-induced promoter assembly, acting upstream of STAT complexes at multiple IFN target loci |
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equired for Zygotic genome activation in mammals |
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play a critical role in regulating expression of SRF/MRTFA-dependent smooth muscle-specific genes |
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central ATPase of the SWI/SNF complex, and a critical factor for the functional activity of nuclear receptor complexes |
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enhancing the transcriptional activation by ligand-bound thyroid hormone receptors in a dose-dependent manner |
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playing an essential role in the genesis of specific chromatin loops expanding the repertoire of their functions |
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antagonistic roles for SMARCA2 and SMARCA4 SWI/SNF complexes in differentiation |
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tumor suppressor and a major factor in lung tumorigenesis |
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required in embryonic stem cell maintenance and in blastocysts |
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cooperating with CBP to constrain TP53 activity and permit cancer cell proliferation |
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interprets differentiation signals and plays a causal role in gene regulation, chromatin structure, and cell fate |
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important role for TFAP2C, SMARCA4, and EOMES in trophoblast stem cell self-renewal |
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required for the regulation E-cadherin and the induction of EMT by ZEB1 |
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acts as a corepressor of ZEB1 to regulate E-cadherin transcription |
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has a critical role in regulating cardiac growth, differentiation and gene expression |
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required during embryogenesis and has a role as a tumor suppressor to maintain genome stability and prevent cancer |
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plays a direct role in maintenance of genomic stability and with SWI/SNF-related complexes are involved in both double-strand break repair and nucleotide excision repair |
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can escorts POLR2A during elongation and is stabilized at regions with a high density of positioned nucleosomes |
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specifically required to increase transcription of templates with positioned nucleosomes |
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SMARCA2/SMARCA4A switch is an indicator of the responsiveness of a gene to heat-shock or IFNG stimulation and may represent an "on-off switch" of gene expression |
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impacts the canonical Wnt pathway at two different levels in vascular endothelium: through transcriptional regulation of both Wnt receptor genes and Wnt target genes |
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similarly coregulates transcription of a subset of Wnt target genes in vascular endothelial cells |
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interprets both differentiation and activation signals and plays a causal role in gene regulation, chromatin structure, and cell fate |
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SMARCA2 and SMARCA4 play critical roles in regulating development of smooth muscle and SMARCA4 has specific functions within vascular and gastrointestinal smooth muscle that cannot be performed by SMARCA2 |
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SMARCA4-mediated chromatin remodeling was crucial for IRF1 access to TRIM22 promoter, thus leading to the transcription of TRIM22 gene |
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SMARCA4 and CHD4 antagonistically modulate Wnt signaling in developing yolk sac vessels to mediate normal vascular remodeling |
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role of SMARCA4/SMARCE1-containing chromatin remodeling complexes in thyroid hormone receptors-regulated gene expression during postembryonic development |
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plays a crucial role in IFNG-induced TRIM22 expression |
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may help IRF1 to overcome the chromatin barrier to activate TRIM22 transcription |
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MBD3 and SMARCA4 antagonistically regulate a common set of genes by regulating promoter nucleosome occupancy |
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role for the mammalian SWI/SNF complex in programmed recombination and repair events that take place during meiosis |
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is required in neural crest cells (NCCs) to direct cardiovascular development |
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important role for SMARCA4 and its downstream pathways in the survival, differentiation, and migration of the multipotent NCCs critical for mammalian cardiovascular development |
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acts downstream of BRCA1 to promote senescence-associated heterochromatin foci (SAHF) formation and senescence |
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MED14 cooperates with SMARCA4 in the differentiation of skeletogenic neural crest |
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SMARCA4, SMARCD2, DPF2 are required for the expression of haematopoietic stem cell associated genes but in contrast to previous results obtained in mouse cells, the three proteins are not required for the expression of MYC regulated genes |
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SMARCA4 and SMARCA5 are catalytic subunits of distinct ATP-dependent chromatin remodeling complexes implicated in transcriptional regulation |