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HGNC UniGene Nucleotide OMIM UCSC
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Symbol SMARCA4 contributors: mct/shn - updated : 22-04-2017
HGNC name SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
HGNC id 11100
  • Brg1 -/- mice died during the periimplantation stage
  • Brg1 heterozygotes for null mutation are predisposed to exencephaly and tumors
  • T lymphocyte-specific Brg1-deficient mice showed profound thymic abnormalities, CD4 derepression at the double negative (DN; CD4- CD8-) stage, and a developmental block at the DN to double positive (CD4+ CD8+) transition
  • BRG1-depleted oocytes completed meiosis and were fertilized but embryos conceived from BRG1-depleted eggs exhibited a zygotic genome activation phenotype including two-cell arrest and reduced transcription for approximately 30% of expressed genes involved in transcription, RNA processing, and cell cycle regulation
  • Brg1 mutant mouse embryos and RNAi knockdown cells exhibit a 50% reduction in replication fork progression rates, which is associated with decreased cell proliferation
  • genetic ablation of Brg1 in murine embryonic gonocytes results in arrest during prophase of meiosis I
  • mice deficient in the expression of Brg1, a subunit of
  • the complex with ATPase activity, showed defects in early B cell development