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FLASH GENE

Symbol

SLURP1

contributors: mct/ - updated : 09-09-2009

HGNC name	secreted LY6/PLAUR domain containing 1
HGNC id	18746

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	MLDD Meleda disease
Location	8q24.3      Physical location : 143.822.362 - 143.823.829
Synonym name	ARS component B
	secreted mammalian Ly-6/urokinase-type plasminogen activator receptor-related protein)-1
	lymphocyte antigen 6-like secreted
	anti-neoplastic urinary protein
Synonym symbol(s)	ARS-B, MDM, ANUP, ARS, SLURP-1, LY6LS

DNA

TYPE	functioning gene
STRUCTURE	1.47 kb     3 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_020427 3 - 537 NP_065160 - 103 - -

EXPRESSION

Rna function	T-B cells, spleen, thymus, dendritic cells, bone marrow, macrophage ; the periodontal ligament, gingival fibroblasts, oral keratinocytes and bone
Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive salivary gland       highly Respiratory lung alveoli       Homo sapiens Skin/Tegument skin       highly Visual eye

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Epithelial barrier/lining

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic granulocyte Respiratory epithelial cell Homo sapiens Skin/Tegument keratinocyte

cell lineage
cell lines
fluid/secretion	detected in the plasma, urine, sweat, saliva and tears

at STAGE

physiological period

fetal

Text	eye, lens, optic nerve, retina, anterior segment, RPE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

lacking the GPI-anchoring signal sequence and at least eight of the ten conserved cysteines

mono polymer

homomer , dimer

HOMOLOGY

Homologene

FAMILY

Ly-6/Upar family

CATEGORY

tumor suppressor

SUBCELLULAR LOCALIZATION	extracellular
text	secreted

basic FUNCTION	implicated in transmembrane signal transduction, cell activation, and cell adhesion
	having a biological role in the epidermis to provide fine tuning of the physiologic regulation of keratinocytes functions through the cholinergic pathways
	may be involved in regulating lymphocyte function via CHRNA-mediated pathways
	its expression in airway epithelial cells is down-regulated by the presence of interleukin IL13, which is abundant in asthmatic airways and plays a key role in the pathogenesis of asthma
	positive allosteric modulator of CHRNA7 signaling, that may mitigate such remodeling of the airway epithelium and diminish production of pro-inflammatory cytokines mediated via CHRNA7

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

binds to CHRNA7 and enhances the amplitude of macroscopic currents induced by acetylcholine, leading to facilitation of apoptosis

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

MLDD

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   decreased due to gene silencing of different nAChR alpha subunits with small hairpin RNA, suggesting that a positive feedback regulation is altered in malignant cells constitutional     --low   in asthma attenuates its negative regulation of airway inflammation constitutional     --low   in asthma likely disrupts epithelial homeostasis, leading to remodeling of the bronchial epithelium and greater susceptibility to infections, such as influenza and pneumonia

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	changes in SLURP1 expression could serve as a marker of airway damage in asthma
Therapy target

ANIMAL & CELL MODELS

Slurp-1 mRNA is down-regulated in the lungs of asthmatic model mice, as compared to healthy mice