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FLASH GENE
Symbol SLURP1 contributors: mct/ - updated : 09-09-2009
HGNC name secreted LY6/PLAUR domain containing 1
HGNC id 18746
ASSOCIATED DISORDERS
corresponding disease(s) MLDD
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --low  
decreased due to gene silencing of different nAChR alpha subunits with small hairpin RNA, suggesting that a positive feedback regulation is altered in malignant cells
constitutional     --low  
in asthma attenuates its negative regulation of airway inflammation
constitutional     --low  
in asthma likely disrupts epithelial homeostasis, leading to remodeling of the bronchial epithelium and greater susceptibility to infections, such as influenza and pneumonia
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • changes in SLURP1 expression could serve as a marker of airway damage in asthma
  • Therapy target
    ANIMAL & CELL MODELS
  • Slurp-1 mRNA is down-regulated in the lungs of asthmatic model mice, as compared to healthy mice