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FLASH GENE

Symbol

SLITRK1

contributors: mct/npt - updated : 12-05-2015

HGNC name	SLIT and NTRK-like family, member 1
HGNC id	20297

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	GTS13 Tourette syndrome, chromosome 13 related
Location	13q31.1      Physical location : 84.451.343 - 84.456.528
Synonym name	slit and trk like gene 1
	leucine rich repeat containing 12
Synonym symbol(s)	LRRC12, KIAA1910, KIAA0918, RP11-395N17.1, FLJ54428, TTM

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
STRUCTURE	5.19 kb     1 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_052910 1 - 5201 NP_443142 - 696 - 2003 14550773 NM_001281503 2 - 4753 NP_001268432 - 696 - -

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain forebrain cerebral cortex frontal cortex highly Homo sapiens   brain basal nuclei striatum   highly Homo sapiens   brain limbic system hippocampus       brain basal nuclei globus pallidus   highly Homo sapiens   brain hindbrain cerebellum

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron Homo sapiens Nervous pyramidal cell Homo sapiens

cell lineage
cell lines	astrocytomas, oligodendrogliomas, gliobastomas, gangliogliomas and primitive neuroectodermal tumors
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	extracellular domains containing two clusters of LRRs (13 LRR (leucine-rich) repeats)
	extracellular domain is secreted and this process is activated by protein kinase C and inhibited by an inhibitor of tumor necrosis factor-alpha converting enzyme (ADAM17)(Kajiwara 2009)

HOMOLOGY

interspecies

ortholog to murine Slitrk1

Homologene

FAMILY

SLITRK family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	plasma membrane
text	integral to membrane

basic FUNCTION	enhancing neurite outgrowth and involved in neuronal differentiation
	role of SLIRTK1 in developmental neuropsychiatric conditions (Kajiwara 2009)
	contributes to the development of corticostriatal-thalamocortical circuits
	implicated in mediating basic neuronal processes, ranging from neurite outgrowth and dendritic elaboration to neuronal survival
	SLITRK1, SLITRK2, SLITK3, SLITRK4, SLITRK5 and SLITRK6 are differentially localized to distinct synapse types and regulate the formation of the respective synapses in an isoform-dependent manner
	SLITRK1, SLITRK2, SLITRK4, and SLITRK5 specifically acted at excitatory synapses in various functional assays

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interaction between SLITRK1 and 14-3-3 proteins (Kajiwara 2009)
	SLITRK1, SLITRK2, SLITK3, SLITRK4, SLITRK5 and SLITRK6 appeared to interact with both PTPRD and PTPRS

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

GTS13

Susceptibility

to Tourette syndrome (minor role ) (Zimprich 2008) to obsessive-compulsive disorders (OCDs), and trichotillomania

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS