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FLASH GENE
Symbol SLITRK1 contributors: mct/npt - updated : 12-05-2015
HGNC name SLIT and NTRK-like family, member 1
HGNC id 20297
Corresponding disease
GTS13 Tourette syndrome, chromosome 13 related
Location 13q31.1      Physical location : 84.451.343 - 84.456.528
Synonym name
  • slit and trk like gene 1
  • leucine rich repeat containing 12
  • Synonym symbol(s) LRRC12, KIAA1910, KIAA0918, RP11-395N17.1, FLJ54428, TTM
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 5.19 kb     1 Exon(s)
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC390413 13 similar to 60S ribosomal protein L7 DHX9P 13q21 DEAH (Asp-Glu-Ala-His) box polypeptide 9 pseudogene CLN5 13q22 ceroid-lipofuscinosis, neuronal 5 FBXL3A 13q22 F-box and leucine-rich repeat protein 3A PAM 5q15 peptidylglycine alpha-amidating monooxygenase SCEL 13q22 sciellin LOC390414 13 similar to chromosome 15 open reading frame 2 FLJ30046 13q22.1 hypothetical protein FLJ30046 EDNRB 13q22 endothelin receptor type B POU4F1 13q21.1-q22 POU domain, class 4, transcription factor 1 C13orf7 13q22.2 chromosome 13 open reading frame 7 LOC341732 13q22.2 similar to 60 kDa heat shock protein, mitochondrial precursor (Hsp60) (60 kDa chaperonin) (CPN60) (Heat shock protein 60) (HSP-60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) (HuCHA60) LOC390415 13 similar to T-complex protein 1, epsilon subunit (TCP-1-epsilon) (CCT-epsilon) C13orf10 13q22.1 chromosome 13 open reading frame 10 NDFIP2 13q22.1 Nedd4 family interacting protein 2 SPRY2 13q31-q32 sprouty homolog 2 (Drosophila) LOC150928 13q22.3 hypothetical LOC150928 SLITRK1 13q31.1 SLIT and NTRK-like family, member 1 VENTX2P2 13q31.1 VENT-like homeobox 2 pseudogene 2 LOC387939 13 LOC387939 SLITRK6 13q31.1 SLIT and NTRK-like family, member 6 LOC390417 13 similar to probable RNA helicase (EC 3.6.1.-) RCK - human SLITRK5 13q31.1 slit and trk like gene 5 LOC387940 13 LOC387940 LOC160824 13q31.2 similar to Transcription factor Sp3 (SPR-2) LOC121727 13q31.2-q31.3 similar to Peroxisome assembly protein 12 (Peroxin-12) (Peroxisome assembly factor-3) (PAF-3) LOC390418 13 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 5201 - 696 - 2003 14550773
    2 - 4753 - 696 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainforebraincerebral cortexfrontal cortexhighly Homo sapiens
     brainbasal nucleistriatum highly Homo sapiens
     brainlimbic systemhippocampus  
     brainbasal nucleiglobus pallidus highly Homo sapiens
     brainhindbraincerebellum  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron Homo sapiens
    Nervouspyramidal cell Homo sapiens
    cell lineage
    cell lines astrocytomas, oligodendrogliomas, gliobastomas, gangliogliomas and primitive neuroectodermal tumors
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • extracellular domains containing two clusters of LRRs (13 LRR (leucine-rich) repeats)
  • extracellular domain is secreted and this process is activated by protein kinase C and inhibited by an inhibitor of tumor necrosis factor-alpha converting enzyme (ADAM17)(Kajiwara 2009)
  • HOMOLOGY
    interspecies ortholog to murine Slitrk1
    Homologene
    FAMILY
  • SLITRK family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
    text integral to membrane
    basic FUNCTION
  • enhancing neurite outgrowth and involved in neuronal differentiation
  • role of SLIRTK1 in developmental neuropsychiatric conditions (Kajiwara 2009)
  • contributes to the development of corticostriatal-thalamocortical circuits
  • implicated in mediating basic neuronal processes, ranging from neurite outgrowth and dendritic elaboration to neuronal survival
  • SLITRK1, SLITRK2, SLITK3, SLITRK4, SLITRK5 and SLITRK6 are differentially localized to distinct synapse types and regulate the formation of the respective synapses in an isoform-dependent manner
  • SLITRK1, SLITRK2, SLITRK4, and SLITRK5 specifically acted at excitatory synapses in various functional assays
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction between SLITRK1 and 14-3-3 proteins (Kajiwara 2009)
  • SLITRK1, SLITRK2, SLITK3, SLITRK4, SLITRK5 and SLITRK6 appeared to interact with both PTPRD and PTPRS
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) GTS13
    Susceptibility
  • to Tourette syndrome (minor role ) (Zimprich 2008)
  • to obsessive-compulsive disorders (OCDs), and trichotillomania
  • Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS