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FLASH GENE
Symbol SLITRK1 contributors: mct/npt - updated : 12-05-2015
HGNC name SLIT and NTRK-like family, member 1
HGNC id 20297
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 5.19 kb     1 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
1 - 5201 - 696 - 2003 14550773
2 - 4753 - 696 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainforebraincerebral cortexfrontal cortexhighly Homo sapiens
 brainbasal nucleistriatum highly Homo sapiens
 brainlimbic systemhippocampus  
 brainbasal nucleiglobus pallidus highly Homo sapiens
 brainhindbraincerebellum  
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron Homo sapiens
Nervouspyramidal cell Homo sapiens
cell lineage
cell lines astrocytomas, oligodendrogliomas, gliobastomas, gangliogliomas and primitive neuroectodermal tumors
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • extracellular domains containing two clusters of LRRs (13 LRR (leucine-rich) repeats)
  • extracellular domain is secreted and this process is activated by protein kinase C and inhibited by an inhibitor of tumor necrosis factor-alpha converting enzyme (ADAM17)(Kajiwara 2009)
  • HOMOLOGY
    interspecies ortholog to murine Slitrk1
    Homologene
    FAMILY
  • SLITRK family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
    text integral to membrane
    basic FUNCTION
  • enhancing neurite outgrowth and involved in neuronal differentiation
  • role of SLIRTK1 in developmental neuropsychiatric conditions (Kajiwara 2009)
  • contributes to the development of corticostriatal-thalamocortical circuits
  • implicated in mediating basic neuronal processes, ranging from neurite outgrowth and dendritic elaboration to neuronal survival
  • SLITRK1, SLITRK2, SLITK3, SLITRK4, SLITRK5 and SLITRK6 are differentially localized to distinct synapse types and regulate the formation of the respective synapses in an isoform-dependent manner
  • SLITRK1, SLITRK2, SLITRK4, and SLITRK5 specifically acted at excitatory synapses in various functional assays
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction between SLITRK1 and 14-3-3 proteins (Kajiwara 2009)
  • SLITRK1, SLITRK2, SLITK3, SLITRK4, SLITRK5 and SLITRK6 appeared to interact with both PTPRD and PTPRS
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) GTS13
    Susceptibility
  • to Tourette syndrome (minor role ) (Zimprich 2008)
  • to obsessive-compulsive disorders (OCDs), and trichotillomania
  • Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS