| basic FUNCTION
| chemorepellent, involved in histogenesis of central nervous system controlling the migrations of neurons and leukocytes of olfactory system |
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play a key role in guiding dorsally projecting cranial motoneurons and in facilitating their neural tube exit |
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SLIT1 and SLIT2, regulate two distinct aspects of intraretinal axon guidance in a region-specific manner  |
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acts via ROBO2 in dendrites as a branching/growth factor but not in guidance, while ROBO2 and ROBO3 function in concert in axons to mediate axonal interactions and respond to Slits as guidance factors |
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multifunctional guidance cues, capable of triggering neurite repulsion, extension, or branching, depending on cell type and developmental context |
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SLIT1 signaling, perhaps in the form of a superficial-to-deep gradient, presents laminar positional cues to ingrowing retinal axons |
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role during the angiogenic process that relies on the directional migration not only of endothelial cells but also of pericytes |
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SLIT2 may act in an autocrine manner on beta cells, whereas SLIT1 and SLIT3 may play both autocrine and paracrine roles |
