| 1 | ROBO1, ROBO2, SLIT1, SLIT2, SLIT3
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| Intraislet SLIT-ROBO signaling is required for beta-cell survival and potentiates insulin secretion.
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| Yang YH, Manning Fox JE, Zhang KL, MacDonald PE, Johnson JD.
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| Proc Natl Acad Sci U S A 110(41):16480-5. doi: 10.1073/pnas.1214312110. Epub 2013 Sep 24.
2013
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| 2 | CASP3, CASP9, MAPK14, ROBO2, SLIT1
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| Local caspase activation interacts with Slit-Robo signaling to restrict axonal arborization.
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| Campbell DS, Okamoto H.
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| J Cell Biol 203(4):657-72. doi: 10.1083/jcb.201303072.
2013
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| 3 | SLIT1, SLIT2, SLIT3
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| The axonal repellent Slit2 inhibits pericyte migration: potential implications in angiogenesis.
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| Guijarro-Muñoz I, Cuesta AM, Alvarez-Cienfuegos A, Geng JG, Alvarez-Vallina L, Sanz L.
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| Exp Cell Res 318(4):371-8. doi: 10.1016/j.yexcr.2011.12.005. Epub 2011 Dec 14.
2012
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| 4 | NCK2, SLIT1
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| The adaptor protein Nck2 mediates Slit1-induced changes in cortical neuron morphology.
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| Round JE, Sun H.
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| Mol Cell Neurosci 47(4):265-73. Epub 2011 May 6.
2011
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| 5 | ROBO2, SLIT1
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| Midbrain dopaminergic axons are guided longitudinally through the diencephalon by Slit/Robo signals.
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| Dugan JP, Stratton A, Riley HP, Farmer WT, Mastick GS.
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| Mol Cell Neurosci 46(1):347-56. Epub 2010 Nov 27.
2011
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| 6 | ATSDL, COL4A5, SLIT1
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| Assembly of lamina-specific neuronal connections by slit bound to type IV collagen.
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| Xiao T, Staub W, Robles E, Gosse NJ, Cole GJ, Baier H.
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| Cell 146(1):164-76. 2011
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| 7 | ROBO2, SLIT1
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| Slit1 promotes regenerative neurite outgrowth of adult dorsal root ganglion neurons in vitro via binding to the Robo receptor.
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| Zhang HY, Zheng LF, Yi XN, Chen ZB, He ZP, Zhao D, Zhang XF, Ma ZJ.
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| J Chem Neuroanat 39(4):256-61. Epub 2010 Feb 19.
2010
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| 8 | ROBO2, ROBO3, SLIT1
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| Distinct roles for Robo2 in the regulation of axon and dendrite growth by retinal ganglion cells.
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| Hocking JC, Hehr CL, Bertolesi GE, Wu JY, McFarlane S.
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| Mech Dev 127(1-2):36-48. Epub 2009 Dec 2.
2010
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| 9 | ROBO2, SLIT1, SLIT2
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| Robo2 is required for Slit-mediated intraretinal axon guidance.
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| Thompson H, Andrews W, Parnavelas JG, Erskine L.
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| Dev Biol 335(2):418-26. Epub 2009 Sep 25.
2009
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| 10 | ROBO2, SLIT1
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| Robo2-Slit1 dependent cell-cell interactions mediate assembly of the trigeminal ganglion.
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| Shiau CE, Lwigale PY, Das RM, Wilson SA, Bronner-Fraser M.
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| Nat Neurosci 11(3):269-76. Epub 2008 Feb 17. 2008
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| 11 | CXCL12, CXCR4, SLIT1, SLIT2
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| SLITs suppress tumor growth in vivo by silencing Sdf1/Cxcr4 within breast epithelium.
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| Marlow R, Strickland P, Lee JS, Wu X, Pebenito M, Binnewies M, Le EK, Moran A, Macias H, Cardiff RD, Sukumar S, Hinck L.
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| Cancer Res 68(19):7819-27. 2008
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| 12 | SLIT1
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| A molecular mechanism for the heparan sulfate dependence of slit-robo signaling.
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| Hussain SA, Piper M, Fukuhara N, Strochlic L, Cho G, Howitt JA, Ahmed Y, Powell AK, Turnbull JE, Holt CE, Hohenester E.
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| J Biol Chem 281(51):39693-8. Epub 2006 Oct 24. 2006
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| 13 | SLIT1
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| Slit-mediated repulsion is a key regulator of motor axon pathfinding in the hindbrain.
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| Hammond R, Vivancos V, Naeem A, Chilton J, Mambetisaeva E, Andrews W, Sundaresan V, Guthrie S.
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| Development 132(20):4483-95. Epub 2005 Sep 14. Erratum in: Development. 2005 Nov;132(22):5125. 2005
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| 14 | SLIT1, SLIT2, SLIT3
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| Comparative genomics on SLIT1, SLIT2, and SLIT3 orthologs.
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| Katoh Y, Katoh M.
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| Oncol Rep 14(5):1351-5.PMID: 16211308 2005
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| 15 | ROBO3, SLIT1
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| The divergent Robo family protein rig-1/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axons.
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| Sabatier C, Plump AS, Le Ma, Brose K, Tamada A, Murakami F, Lee EY, Tessier-Lavigne M.
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| Cell 117(2):157-69. 2004
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| 16 | IRX4, SLIT1
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| Irx4-mediated regulation of Slit1 expression contributes to the definition of early axonal paths inside the retina.
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| Jin Z, Zhang J, Klar A, Chédotal A, Rao Y, Cepko CL, Bao ZZ.
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| Development 130(6):1037-48.
2003
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| 17 | ROBO1, ROBO2, ROBO3, SLIT1, SLIT2, SLIT3
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| Slit proteins prevent midline crossing and determine the dorsoventral position of major axonal pathways in the mammalian forebrain.
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| Bagri A, Marin O, Plump AS, Mak J, Pleasure SJ, Rubenstein JL, Tessier-Lavigne M.
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| Neuron 33(2):233-48. 2002
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| 18 | SLIT1, SLIT2, SLIT3
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| The neuronal repellent Slit inhibits leukocyte chemotaxis induced by chemotactic factors.
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| Wu JY, Feng L, Park HT, Havlioglu N, Wen L, Tang H, Bacon KB, Jiang Zh, Zhang Xc, Rao Y.
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| Nature 410(6831):948-52. 2001
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| 19 | SLIT1, SLIT2, SLIT3
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| Dual trafficking of Slit3 to mitochondria and cell surface demonstrates novel localization for Slit protein.
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| Little MH, Wilkinson L, Brown DL, Piper M, Yamada T, Stow JL.
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| Am J Physiol Cell Physiol 281(2):C486-95.PMID: 11443047 2001
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| 20 | SLIT1, SLIT3, GPC1
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| Mammalian homologues of the Drosophila slit protein are ligands of the heparan sulfate proteoglycan glypican-1 in brain.
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| Liang Y, et al.
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| J Biol Chem 274(25):17885-92. 1999
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| 21 | LDB1, LGI1, PPP1R3C, SLIT1
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| Expression analysis of 21 transcripts physically anchored within the chromosomal region 10q24.
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| Nobile C, Pitzalis S.
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| Genomics 62(1):86-9 1999
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| 22 | SLIT2, SLIT1, SLIT2, SLIT3
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| Biochemical purification of a mammalian slit protein as a positive regulator of sensory axon elongation and branching.
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| Wang KH, Brose K, Arnott D, Kidd T, Goodman CS, Henzel W, Tessier-Lavigne M.
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| Cell 96(6):771-84. 1999
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| 23 | SLIT1, SLIT2, SLIT3
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| Vertebrate slit, a secreted ligand for the transmembrane protein roundabout, is a repellent for olfactory bulb axons.
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| Li HS, Chen JH, Wu W, Fagaly T, Zhou L, Yuan W, Dupuis S, Jiang ZH, Nash W, Gick C, Ornitz DM, Wu JY, Rao Y.
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| Cell 96(6):807-18. 1999
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| 24 | ROBO1, ROBO2, ROBO3, SLIT1, SLIT2, SLIT3
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| Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance.
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| Brose K, Bland KS, Wang KH, Arnott D, Henzel W, Goodman CS, Tessier-Lavigne M, Kidd T.
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| Cell 96(6):795-806. 1999
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| 25 | SLIT1, SLIT2, SLIT3
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| Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system.
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| Itoh A, et al.
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| Brain Res Mol Brain Res 62(2):175-86 1998
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| 26 | FAT2, CELSR3, CELSR2, MEGF6, MEGF8, MEGF9, LRP4, SLIT1, SLIT3
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| Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening.
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| Nakayama M, Nakajima D, Nagase T, Nomura N, Seki N, Ohara O.
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| Genomics 51(1):27-34. 1998
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