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FLASH GENE
Symbol SLC6A7 contributors: mct - updated : 16-02-2008
HGNC name solute carrier family 6 (neurotransmitter transporter, L-proline), member 7
HGNC id 11054
Location 5q32      Physical location : 149.569.519 - 149.590.634
Synonym name
  • brain-specific L-proline transporter
  • sodium-dependent proline transporter
    • Synonym symbol(s) PROT
    DNA
    TYPE functioning gene
    STRUCTURE 21.12 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 3756 70.8 636 - PMID: 20431603
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestine    
    Nervousbrain    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • 12 transmembrane segments (12TM)
    • HOMOLOGY
    Homologene
    FAMILY
  • sodium:neurotransmitter symporter (SNF) family
    • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    text located in synaptosomal membranes
    basic FUNCTION
  • Na+ (and Cl-) dependent plasma membrane transporter of proline, high affinity
  • playing a presynaptic regulatory role in excitatory synaptic transmission
  • transporter for an excitatory neurotransmitter of L-proline
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to asthma
    Variant & Polymorphism other significant associations between genetic variants of the SLC6A7 gene and asthma
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS