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FLASH GENE
Symbol SLC6A7 contributors: mct - updated : 16-02-2008
HGNC name solute carrier family 6 (neurotransmitter transporter, L-proline), member 7
HGNC id 11054
DNA
TYPE functioning gene
STRUCTURE 21.12 kb     14 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 3756 70.8 636 - PMID: 20431603
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestine    
Nervousbrain    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 12 transmembrane segments (12TM)
  • HOMOLOGY
    Homologene
    FAMILY
  • sodium:neurotransmitter symporter (SNF) family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    text located in synaptosomal membranes
    basic FUNCTION
  • Na+ (and Cl-) dependent plasma membrane transporter of proline, high affinity
  • playing a presynaptic regulatory role in excitatory synaptic transmission
  • transporter for an excitatory neurotransmitter of L-proline
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to asthma
    Variant & Polymorphism other significant associations between genetic variants of the SLC6A7 gene and asthma
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS