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FLASH GENE

Symbol

SLC6A15

contributors: npt/ - updated : 23-08-2007

HGNC name	solute carrier family 6 (neutral amino acid transporter), member 15
HGNC id	13621

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	12q21.31      Physical location : 85.253.268 - 85.306.606
Synonym name	solute carrier family 6 (neurotransmitter transporter), member 15
	homolog of rat orphan transporter v7-3
	sodium neurotransmitter symporter family 73
	sodium-coupled branched-chain amino-acid transporter 1
	homolog of rat orphan transporter v7-3
	sodium/chloride dependent neurotransmitter transporter Homo sapiens orphan neurotransmitter transporter NTT7
Synonym symbol(s)	V7.3, NTT6, NTT73, FLJ10316, SBAT1

DNA

TYPE	functioning gene
STRUCTURE	53.34 kb     12 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001146335 - - 4362 NP_001139807 - 623 - - NM_182767 - - 4830 NP_877499 - 730 - Takanaga (2005) NM_018057 - - 4260 NP_060527 - 289 - Takanaga (2005)

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol digestive mouth gingiva     highly Nervous brain diencephalon amygdala     nervous brain basal nuclei putamen     Nervous brain basal nuclei corpus callosum     Reproductive female system placenta         male system testis       Skin/Tegument skin         Visual eye

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal     Nervous central       Nervous peripherous

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	brain, primitive neurectoderm, eye, lens retina

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	putative twelve membrane-spanning domains
	five potential N-linked extracellular glycosylation sites

HOMOLOGY

interspecies

homolog to rattus V7.3

Homologene

FAMILY

neurotransmitter symporter family (SNF)

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	involved in neurotransmitter transport
	involved in the transport of branched-chain amino acids, particularly leucine, that may be an important source of amino nitrogen for neurotransmitter synthesis in glutamatergic and GABAergic neurons
	may have minor roles in synaptosomal proline uptake, leucine uptake and behaviors (Drgonova 2007)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

nervous system

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS