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FLASH GENE
Symbol SLC6A15 contributors: npt/ - updated : 23-08-2007
HGNC name solute carrier family 6 (neutral amino acid transporter), member 15
HGNC id 13621
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
digestivemouthgingiva  highly
Nervousbraindiencephalonamygdala  
nervousbrainbasal nucleiputamen  
Nervousbrainbasal nucleicorpus callosum  
Reproductivefemale systemplacenta   
 male systemtestis   
Skin/Tegumentskin    
Visualeye    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
Nervouscentral   
Nervousperipherous   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text brain, primitive neurectoderm, eye, lens retina
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • putative twelve membrane-spanning domains
  • five potential N-linked extracellular glycosylation sites
  • HOMOLOGY
    interspecies homolog to rattus V7.3
    Homologene
    FAMILY
  • neurotransmitter symporter family (SNF)
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in neurotransmitter transport
  • involved in the transport of branched-chain amino acids, particularly leucine, that may be an important source of amino nitrogen for neurotransmitter synthesis in glutamatergic and GABAergic neurons
  • may have minor roles in synaptosomal proline uptake, leucine uptake and behaviors (Drgonova 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS nervous system
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS