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FLASH GENE

Symbol

SLC44A1

contributors: npt - updated : 10-01-2005

HGNC name	solute carrier family 44, member 1
HGNC id	18798

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	9q31.2      Physical location : 108.006.928 - 108.153.680
Synonym name	CD92 protein
	choline transporter-like protein 1
	CDW92 antigen
Synonym symbol(s)	CTL1, CHTL1, CDW92, CD92, RP11-287A8.1

DNA

TYPE	functioning gene
STRUCTURE	157.00 kb     17 Exon(s)

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 - - 1965 - 654 - Wille 17 exons variant 2 - - 4301 73.3 657 - Wille 15 exons

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon     Nervous brain           spinal cord         Respiratory lung

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic leukocyte Blood/Hematopoietic monocyte Blood/Hematopoietic neutrophil Lymphoid/Immune dendritic cell

cell lineage
cell lines	sarcoma cell lines, myeloid and T cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	ten transmembrane domains
	three potential N-glycosylation sites
	a potential immunoreceptor tyrosine-based inhibitory motif (ITIM)

HOMOLOGY

interspecies	homolog to murine Cdw92
	ortholog to rattus CTL1

Homologene

FAMILY	CTL (choline transporter-like) family
	solute carrier family 44

CATEGORY

transport

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	choline transporter activity
	playing a crucial role in the regulation of the function of leukocytes and particularly dendritic cells

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

inhibited by

ionomycin or calcium ionophore

Other

up-regulated by IL10

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS