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FLASH GENE
Symbol SLC44A1 contributors: npt - updated : 10-01-2005
HGNC name solute carrier family 44, member 1
HGNC id 18798
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 1965 - 654 - Wille
17 exons
- - 4301 73.3 657 - Wille
15 exons
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon  
Nervousbrain    
 spinal cord    
Respiratorylung    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
Blood/Hematopoieticmonocyte
Blood/Hematopoieticneutrophil
Lymphoid/Immunedendritic cell
cell lineage
cell lines sarcoma cell lines, myeloid and T cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • ten transmembrane domains
  • three potential N-glycosylation sites
  • a potential immunoreceptor tyrosine-based inhibitory motif (ITIM)
  • HOMOLOGY
    interspecies homolog to murine Cdw92
    ortholog to rattus CTL1
    Homologene
    FAMILY
  • CTL (choline transporter-like) family
  • solute carrier family 44
  • CATEGORY transport
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • choline transporter activity
  • playing a crucial role in the regulation of the function of leukocytes and particularly dendritic cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    inhibited by ionomycin or calcium ionophore
    Other up-regulated by IL10
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS