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FLASH GENE
Symbol SLC39A10 contributors: mct/npt - updated : 18-03-2009
HGNC name solute carrier family 39 (zinc transporter), member 10
HGNC id 20861
Location 2q32.3      Physical location : 196.521.531 - 196.602.425
Synonym name
  • LIV1 protein homolog
  • zinc importer 10
  • solute carrier family 39 (metal ion transporter), member 10
  • Zrt- and Irt-like protein 10
  • Synonym symbol(s) FLJ90515, KIAA1265, DKFZp564L2123, LZT-Hs2, Zip10, DKFZp781L10106, MGC126565, MGC138428
    DNA
    TYPE functioning gene
    STRUCTURE 80.89 kb     10 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text Variants 1 and 2 encode the same protein
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 5386 94 831 - Taylor (2003)
    10 - 5337 94 831 - Taylor (2003)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Reproductivefemale systemovary   
     male systemtestis   
    Respiratorylung    
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • zinc transporter ZIP motif
  • a long N terminus
  • eight putative transmembrane domains
  • a short C terminus
  • HOMOLOGY
    Homologene
    FAMILY
  • ZIP transporter family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • may be involved in heavy metal ion transport
  • involved in the control of intracellular zinc homoeostasis
  • involved in the invasive behavior of breast cancer cells, playing an essential role in the migratory activity of highly metastatic breast cancer cells (Kagara 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    expression of zinc transporter protein in intestine and kidney is positively regulated by thyroid hormones
    constitutional     --over  
    in hyperthyroid subject
    constitutional     --low  
    in hypothyroid subject
    Susceptibility
    Variant & Polymorphism
    Candidate gene possible marker for the metastatic phenotype of breast cancer
    Marker
    Therapy target promising target of novel treatment strategies (Kagara 2007)
    ANIMAL & CELL MODELS
    rZip10 (Slc39a10) involved in zinc uptake across rat renal brush-border membrane (Kaler 2007)