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FLASH GENE
Symbol SLC39A10 contributors: mct/npt - updated : 12-11-2021
HGNC name solute carrier family 39 (zinc transporter), member 10
HGNC id 20861
Location 2q32.3      Physical location : 196.521.531 - 196.602.425
Synonym name
  • LIV1 protein homolog
  • zinc importer 10
  • solute carrier family 39 (metal ion transporter), member 10
  • Zrt- and Irt-like protein 10
    • Synonym symbol(s) FLJ90515, KIAA1265, DKFZp564L2123, LZT-Hs2, Zip10, DKFZp781L10106, MGC126565, MGC138428
    DNA
    TYPE functioning gene
    STRUCTURE 161.76 kb     10 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text Variants 1 and 2 encode the same protein
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 5219 94 831 - 2019 30520657
    10 - 5222 94 831 - 2019 30520657
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Reproductivefemale systemovary   
     male systemtestis   
    Respiratorylung    
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • zinc transporter ZIP motif
  • a long N terminus
  • eight putative transmembrane domains
  • a short C terminus
    • HOMOLOGY
    Homologene
    FAMILY
  • ZIP transporter family
    • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • may be involved in heavy metal ion transport
  • involved in the control of intracellular zinc homoeostasis
  • involved in the invasive behavior of breast cancer cells, playing an essential role in the migratory activity of highly metastatic breast cancer cells (Kagara 2007)
  • mediated Zn homeostasis is essential for early B-cell survival
  • role of SLC39A10 in cell survival during early B-cell development, underscoring the importance of Zn homeostasis in immune system maintenance
  • likely SLC39A10 plays a role in promoting the survival of macrophages through a Zn/TP53-dependent axis in response to inflammatory stimuli
  • SLC39A10-mediated zinc distribution is crucial for epidermal homeostasis via Histone acetyltransferase (HAT)
  • SLC39A10/SLC39A6 heteromer is essential for the zinc-mediated trigger of mitosis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SLC39A10 likely functions as a positive regulator of PTPRC to modulate the BCR signal strength, thereby setting a threshold for BCR signaling in humoral immune responses
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    expression of zinc transporter protein in intestine and kidney is positively regulated by thyroid hormones
    constitutional     --over  
    in hyperthyroid subject
    constitutional     --low  
    in hypothyroid subject
    Susceptibility
    Variant & Polymorphism
    Candidate gene possible marker for the metastatic phenotype of breast cancer
    Marker
  • mRNA expression could be used as a possible biomarker for the aggressive behavior of renal cell carcinoma (RCC)
    • Therapy target promising target of novel treatment strategies (Kagara 2007)
    SystemTypeDisorderPubmed
    cancerurinary 
    promising target of novel treatment strategies in renal cell carcinoma (RCC)
    ANIMAL & CELL MODELS
    rZip10 (Slc39a10) involved in zinc uptake across rat renal brush-border membrane (Kaler 2007)