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FLASH GENE
Symbol SLC39A1 contributors: mct/npt - updated : 24-03-2010
HGNC name solute carrier family 39 (zinc transporter), member 1
HGNC id 12876
Location 1q21.3      Physical location : 153.931.588 - 153.940.188
Synonym name
  • zinc/iron regulated transporter-like
  • Zrt- and Irt-like protein 1
  • Synonym symbol(s) ZIP1, ZIRTL
    DNA
    TYPE functioning gene
    SPECIAL FEATURE
    text situated at the telomeric end of the epidermal differentiation complex (see EDC@)
    STRUCTURE 8.60 kb     5 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site   transcription factor
    text structure
  • critical roles for SP1 and CREB1 in transcriptional regulation of SLC39A1 gene in prostate cancer cells (Makhov 2009)
  • MAPPING cloned Y linked N status provisional
    regionally located in the region of epidermal differentiation complex,mapping outside the critical region for juvenile hemochromatosis (HFE2)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 2445 34.1 324 - Lioumi (1999)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
     intestinesmall intestine  highly
    Reproductivefemale systemuteruscervix highly
     female systemplacenta  highly
     male systemprostate  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skeletonosteoclast
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • eight transmembrane segments
  • nine possible N myristylation sites
  • a potential protein kinase
  • C phosphorylation site
  • four potential protein kinase II phosphorylation sites
  • HOMOLOGY
    Homologene
    FAMILY
  • ZIP transporter family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text integral membrane protein
    basic FUNCTION
  • di, tri-valent inorganic cation transporter
  • major zinc uptake transporter for the accumulation of zinc in prostate cells
  • playing a role in osteoclast activity
  • important zinc uptake transporter involved in the unique ability of prostate cells to accumulate high cellular zinc levels (Desouki 2007)
  • important for the extraction of zinc from circulation as the primary source of cellular zinc (Desouki 2007)
  • have unique cell-specific functions during adaptation to zinc deficiency (Kambe 2009)
  • involved in the initiation of synaptonemal complex formation, is also important for nonexchange chromosomes segregation (Newnham 2010)
  • promotes tethering of nonexchange chromosomes at their centromeres throughout meiotic prophase, and this tethering correlates with improved segregation at the first meiotic division (Newnham 2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in prostate adenocarcinoma (Desouki 2007)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS