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FLASH GENE

Symbol

SLC39A1

contributors: mct/npt - updated : 24-03-2010

HGNC name	solute carrier family 39 (zinc transporter), member 1
HGNC id	12876

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1q21.3      Physical location : 153.931.588 - 153.940.188
Synonym name	zinc/iron regulated transporter-like
	Zrt- and Irt-like protein 1
Synonym symbol(s)	ZIP1, ZIRTL

DNA

TYPE	functioning gene
SPECIAL FEATURE
text	situated at the telomeric end of the epidermal differentiation complex (see EDC@)
STRUCTURE	8.60 kb     5 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
	Binding site   transcription factor
text structure	critical roles for SP1 and CREB1 in transcriptional regulation of SLC39A1 gene in prostate cancer cells (Makhov 2009)

MAPPING

cloned

Y

linked

N

status

provisional

regionally located

in the region of epidermal differentiation complex,mapping outside the critical region for juvenile hemochromatosis (HFE2)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_014437 5 - 2445 NP_055252 34.1 324 - Lioumi (1999)

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive esophagus       highly   intestine small intestine     highly Reproductive female system uterus cervix   highly   female system placenta     highly   male system prostate     highly

cells

System Cell Pubmed Species Stage Rna symbol Skeleton osteoclast

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	eight transmembrane segments
	nine possible N myristylation sites
	a potential protein kinase
	C phosphorylation site
	four potential protein kinase II phosphorylation sites

HOMOLOGY

Homologene

FAMILY

ZIP transporter family

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum
text	integral membrane protein

basic FUNCTION	di, tri-valent inorganic cation transporter
	major zinc uptake transporter for the accumulation of zinc in prostate cells
	playing a role in osteoclast activity
	important zinc uptake transporter involved in the unique ability of prostate cells to accumulate high cellular zinc levels (Desouki 2007)
	important for the extraction of zinc from circulation as the primary source of cellular zinc (Desouki 2007)
	have unique cell-specific functions during adaptation to zinc deficiency (Kambe 2009)
	involved in the initiation of synaptonemal complex formation, is also important for nonexchange chromosomes segregation (Newnham 2010)
	promotes tethering of nonexchange chromosomes at their centromeres throughout meiotic prophase, and this tethering correlates with improved segregation at the first meiotic division (Newnham 2010)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

active transport

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	Zn2+

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in prostate adenocarcinoma (Desouki 2007)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS