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FLASH GENE
Symbol SLC39A1 contributors: mct/npt - updated : 24-03-2010
HGNC name solute carrier family 39 (zinc transporter), member 1
HGNC id 12876
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 2445 34.1 324 - Lioumi (1999)
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
 intestinesmall intestine  highly
Reproductivefemale systemuteruscervix highly
 female systemplacenta  highly
 male systemprostate  highly
cells
SystemCellPubmedSpeciesStageRna symbol
Skeletonosteoclast
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • eight transmembrane segments
  • nine possible N myristylation sites
  • a potential protein kinase
  • C phosphorylation site
  • four potential protein kinase II phosphorylation sites
  • HOMOLOGY
    Homologene
    FAMILY
  • ZIP transporter family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text integral membrane protein
    basic FUNCTION
  • di, tri-valent inorganic cation transporter
  • major zinc uptake transporter for the accumulation of zinc in prostate cells
  • playing a role in osteoclast activity
  • important zinc uptake transporter involved in the unique ability of prostate cells to accumulate high cellular zinc levels (Desouki 2007)
  • important for the extraction of zinc from circulation as the primary source of cellular zinc (Desouki 2007)
  • have unique cell-specific functions during adaptation to zinc deficiency (Kambe 2009)
  • involved in the initiation of synaptonemal complex formation, is also important for nonexchange chromosomes segregation (Newnham 2010)
  • promotes tethering of nonexchange chromosomes at their centromeres throughout meiotic prophase, and this tethering correlates with improved segregation at the first meiotic division (Newnham 2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in prostate adenocarcinoma (Desouki 2007)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS