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FLASH GENE

Symbol

SLC38A3

contributors: shn/npt - updated : 10-01-2009

HGNC name	solute carrier family 38, member 3
HGNC id	18044

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	3p21.3      Physical location : 50.242.691 - 50.258.405
Synonym name	system N1 Na+ and H+-coupled glutamine transporter
	N-system amino acid transporter 1
	G17
	SNAT3
Synonym symbol(s)	G17, SN1, SNAT3, NAT1

DNA

TYPE	functioning gene
STRUCTURE	15.72 kb     16 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

Map	By physical cloning methodologies and bioinformatic computational analyses, SLC38A3 has been localized in a region from a lung cancer tumor suppressor gene on chromosome 3p21.3.
Authors	Lerman and Minna (2000)

regionally located

pter - D3S3604 - D3S3667 - SLC38A3 - D3S1568 - D3S1621 - cen

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed SLC38A3 16 - 2572 55.6 504 - -

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Digestive liver       highly Endocrine pancreas       highly Nervous nerve       highly Urinary kidney       highly Visual eye       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular

cells

System Cell Pubmed Species Stage Rna symbol Digestive hepatocyte Nervous astrocyte Visual amacrine cell Visual bipolar cell Visual cone photoreceptor Visual ganglion cell Visual horizontal association cell Visual Muller cell Visual rod photoreceptor

cell lineage
cell lines	lung cancer cell line
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

10 to 11 transmembrane helices and an aromatic amino acid permease-2 domain

HOMOLOGY

interspecies

ortholog to solute carrier family 38 member 3 (Slc38a3), mouse

Homologene

FAMILY

amino acid/polyamine transporter 2 family

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	SN1 is an isoform of the system N Glutamine Transporters which is the principal mediator of glutamine transport in retinal Müller cells and contributes significantly to glutamine uptake in ganglion cells and, hence,
	contributes to the retinal glutamate-glutamine cycle
	plays an important role in the release of glutamine from brain astrocytes and the uptake of glutamine into hepatocytes (Broer 2009)
	involved in glutamine transport in the liver and in pancreatic beta-cells (Broer 2009)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

aminoacid

signaling

neurotransmission , signal transduction

nitrogen

a component

INTERACTION

DNA

RNA

small molecule
	Na(+)
	H(+)

protein

target for the ubiquitin ligase NEDD4L, which is inactivated by the serum and glucocorticoid inducible kinase SGK1, its isoform SGK3, and protein kinase B

cell & other

REGULATION

inhibited by

Phe, Asp, Glu, Lys, Arg, Ile, Val and Gly

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   is a marker of primary malignant gliomas in situ

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS