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FLASH GENE
Symbol SLC38A3 contributors: shn/npt - updated : 10-01-2009
HGNC name solute carrier family 38, member 3
HGNC id 18044
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 10 to 11 transmembrane helices and an aromatic amino acid permease-2 domain
    • HOMOLOGY
    interspecies ortholog to solute carrier family 38 member 3 (Slc38a3), mouse
    Homologene
    FAMILY
  • amino acid/polyamine transporter 2 family
    • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • SN1 is an isoform of the system N Glutamine Transporters which is the principal mediator of glutamine transport in retinal Müller cells and contributes significantly to glutamine uptake in ganglion cells and, hence,
    • contributes to the retinal glutamate-glutamine cycle
  • plays an important role in the release of glutamine from brain astrocytes and the uptake of glutamine into hepatocytes (Broer 2009)
  • involved in glutamine transport in the liver and in pancreatic beta-cells (Broer 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism aminoacid
    signaling neurotransmission , signal transduction
    nitrogen
    a component
    INTERACTION
    DNA
    RNA
    small molecule
  • Na(+)
  • H(+)
    • protein
  • target for the ubiquitin ligase NEDD4L, which is inactivated by the serum and glucocorticoid inducible kinase SGK1, its isoform SGK3, and protein kinase B
    • cell & other
    REGULATION
    inhibited by Phe, Asp, Glu, Lys, Arg, Ile, Val and Gly
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    is a marker of primary malignant gliomas in situ
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS