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FLASH GENE

Symbol

SLC34A2

contributors: mct - updated : 23-01-2013

HGNC name	solute carrier family 34 (sodium phosphate), member 2
HGNC id	11020

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	PLAM pulmonary alveolar microlithiasis
Location	4p15.2      Physical location : 25.657.434 - 25.680.366
Synonym name	sodium-dependent phosphate transport protein 2B
Synonym symbol(s)	NAPI3B, NAPI-IIb, NPTIIb, FLJ90534, Napi-2b, FLJ90534, Npt2b, MX35, NAPI2b

DNA

TYPE	functioning gene
STRUCTURE	22.94 kb     13 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_006424 13 - 4167 NP_006415 - 690 - 1999 10610722 NM_001177998 13 - 4164 NP_001171469 - 689 - 1999 10610722 NM_001177999 13 - 4187 NP_001171470 - 689 - 1999 10610722

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine     highly Rattus norvegicus Reproductive female system breast     highly Homo sapiens Respiratory lung       highly Homo sapiens   respiratory tract trachea       Urinary kidney

cells

System Cell Pubmed Species Stage Rna symbol Digestive enterocyte Rattus norvegicus Respiratory alveolar cell type 2

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a cysteine-rich-N terminal region
	eleven transmembrane domains
	a PDZ binding motif at its C terminus

HOMOLOGY

Homologene

FAMILY

solute carrier family 34, sodium/phosphate

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	having sodium-dependent phosphate transporter activity
	may be the main phosphate transport protein in the intestinal brush border membrane
	SLC34A1, SLC34A2 expression seem regulated by phosphate in a manner consistent with their playing a role in transcellular P(i) flux during mineralization (PMUID: 17310099)
	may have a role in the synthesis of surfactant in lungs alveoli
	associated with Sodium-lithium countertransport activity and blood pressure
	Na(+)-dependent Pi (Phosphate inorganic) co-transporter, which is expressed in various adult tissues and mediates transport of extracellular Pi ions coupling with Na(+) ion
	plays potentially an important role in Pi absorption from maternal circulation
	contributes to maintaining phosphate homeostasis in the setting of normal renal function
	SLC9A3R1 associates with SLC34A2 in enterocytes and regulates SLC34A2 adaptation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

SLC9A3R1 associates with SLC34A2 but not PDZK1

cell & other

REGULATION

inhibited by

EGF

ASSOCIATED DISORDERS

corresponding disease(s)

PLAM

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in breast and lung tumors tumoral     --over   in well-differentiated endometrioid and papillary serous ovarian carcinomas compared to low-differentiated endometrioid carcinomas, benign serous cystoadenomas and normal ovary

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	upregulation of SLC34A2 gene expression in well-differentiated tumors in ovarian cancerogenesis, and potential marker for ovarian cancer diagnosis and prognosis
Therapy target
	System Type Disorder Pubmed miscelleaneous urinary chronic kidney disease targeting SLC34A2 in addition to using dietary phosphorus binders may be a therapeutic approach to modulate serum phosphate in chronic kidney disease

ANIMAL & CELL MODELS

homozygous NaPi-IIb deficient-mice died in utero soon after implantation, indicating that NaPi-IIb was essential for early embryonic development