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FLASH GENE
Symbol SLC34A2 contributors: mct - updated : 23-01-2013
HGNC name solute carrier family 34 (sodium phosphate), member 2
HGNC id 11020
Corresponding disease
PLAM pulmonary alveolar microlithiasis
Location 4p15.2      Physical location : 25.657.434 - 25.680.366
Synonym name
  • sodium-dependent phosphate transport protein 2B
  • Synonym symbol(s) NAPI3B, NAPI-IIb, NPTIIb, FLJ90534, Napi-2b, FLJ90534, Npt2b, MX35, NAPI2b
    DNA
    TYPE functioning gene
    STRUCTURE 22.94 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Physical map
    MGC29898 4p15.32 hypothetical protein MGC29898 KCNIP4 4p15.32 Kv channel interacting protein 4 FLJ30194 4p15.32 hypothetical protein FLJ30194 GPR125 4p15.32-p15.31 G protein-coupled receptor 125 GBA3 4p15.31 glucosidase, beta, acid 3 (cytosolic) PPARGC1 4p15.1 peroxisome proliferative activated receptor, gamma, coactivator 1 DHX15 4p15.3 DEAH (Asp-Glu-Ala-His) box polypeptide 15 LOC391640 4 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP) SOD3 4p16.3-q21 superoxide dismutase 3, extracellular DKFZp761B107 4p15.31 hypothetical protein DKFZp761B107 LGI2 4p15.31 leucine-rich repeat LGI family, member 2 SLA/LP 4p15.31 soluble liver antigen/liver pancreas antigen PI4K2B 4p15.31 phosphatidylinositol 4-kinase type-II beta ANAPC4 4p15.31 anaphase-promoting complex subunit 4 LOC345348 4p15.31 similar to D-myo-inositol-3-phosphate synthase LOC391641 4 similar to chloroquine resistance marker protein SLC34A2 4p15.3-p15.1 solute carrier family 34 (sodium phosphate), member 2 KIAA0746 4p15.2 solute carrier family 34 (sodium phosphate), member 2 LOC389203 4 hypothetical gene supported by BC032431 RBPSUH 9p13-p12 recombining binding protein suppressor of hairless (Drosophila) CCKAR 4p15.2-p15.1 cholecystokinin A receptor FLJ11082 4p15.31 hypothetical protein FLJ11082 STIM2 4p15.2 stromal interaction molecule 2 LOC389204 4 LOC389204 MRPL51P1 4p15.2 LOC389204 LOC391642 4 similar to Immunoglobulin-binding protein 1 (CD79a-binding protein 1) (B cell signal transduction molecule alpha 4) (Alpha 4 protein) LOC285509 4p15.2 hypothetical LOC285509 LOC391643 4 similar to mesoderm specific transcript isoform a; paternally expressed gene 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 4167 - 690 - 1999 10610722
    13 - 4164 - 689 - 1999 10610722
    13 - 4187 - 689 - 1999 10610722
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly Rattus norvegicus
    Reproductivefemale systembreast  highly Homo sapiens
    Respiratorylung   highly Homo sapiens
     respiratory tracttrachea   
    Urinarykidney    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestiveenterocyte Rattus norvegicus
    Respiratoryalveolar cell type 2
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a cysteine-rich-N terminal region
  • eleven transmembrane domains
  • a PDZ binding motif at its C terminus
  • HOMOLOGY
    Homologene
    FAMILY solute carrier family 34, sodium/phosphate
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • having sodium-dependent phosphate transporter activity
  • may be the main phosphate transport protein in the intestinal brush border membrane
  • SLC34A1, SLC34A2 expression seem regulated by phosphate in a manner consistent with their playing a role in transcellular P(i) flux during mineralization (PMUID: 17310099)
  • may have a role in the synthesis of surfactant in lungs alveoli
  • associated with Sodium-lithium countertransport activity and blood pressure
  • Na(+)-dependent Pi (Phosphate inorganic) co-transporter, which is expressed in various adult tissues and mediates transport of extracellular Pi ions coupling with Na(+) ion
  • plays potentially an important role in Pi absorption from maternal circulation
  • contributes to maintaining phosphate homeostasis in the setting of normal renal function
  • SLC9A3R1 associates with SLC34A2 in enterocytes and regulates SLC34A2 adaptation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SLC9A3R1 associates with SLC34A2 but not PDZK1
  • cell & other
    REGULATION
    inhibited by EGF
    ASSOCIATED DISORDERS
    corresponding disease(s) PLAM
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in breast and lung tumors
    tumoral     --over  
    in well-differentiated endometrioid and papillary serous ovarian carcinomas compared to low-differentiated endometrioid carcinomas, benign serous cystoadenomas and normal ovary
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • upregulation of SLC34A2 gene expression in well-differentiated tumors in ovarian cancerogenesis, and potential marker for ovarian cancer diagnosis and prognosis
  • Therapy target
    SystemTypeDisorderPubmed
    miscelleaneousurinarychronic kidney disease
    targeting SLC34A2 in addition to using dietary phosphorus binders may be a therapeutic approach to modulate serum phosphate in chronic kidney disease
    ANIMAL & CELL MODELS
  • homozygous NaPi-IIb deficient-mice died in utero soon after implantation, indicating that NaPi-IIb was essential for early embryonic development