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FLASH GENE
Symbol SLC34A2 contributors: mct - updated : 23-01-2013
HGNC name solute carrier family 34 (sodium phosphate), member 2
HGNC id 11020
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 4167 - 690 - 1999 10610722
13 - 4164 - 689 - 1999 10610722
13 - 4187 - 689 - 1999 10610722
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly Rattus norvegicus
Reproductivefemale systembreast  highly Homo sapiens
Respiratorylung   highly Homo sapiens
 respiratory tracttrachea   
Urinarykidney    
cells
SystemCellPubmedSpeciesStageRna symbol
Digestiveenterocyte Rattus norvegicus
Respiratoryalveolar cell type 2
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a cysteine-rich-N terminal region
  • eleven transmembrane domains
  • a PDZ binding motif at its C terminus
  • HOMOLOGY
    Homologene
    FAMILY solute carrier family 34, sodium/phosphate
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • having sodium-dependent phosphate transporter activity
  • may be the main phosphate transport protein in the intestinal brush border membrane
  • SLC34A1, SLC34A2 expression seem regulated by phosphate in a manner consistent with their playing a role in transcellular P(i) flux during mineralization (PMUID: 17310099)
  • may have a role in the synthesis of surfactant in lungs alveoli
  • associated with Sodium-lithium countertransport activity and blood pressure
  • Na(+)-dependent Pi (Phosphate inorganic) co-transporter, which is expressed in various adult tissues and mediates transport of extracellular Pi ions coupling with Na(+) ion
  • plays potentially an important role in Pi absorption from maternal circulation
  • contributes to maintaining phosphate homeostasis in the setting of normal renal function
  • SLC9A3R1 associates with SLC34A2 in enterocytes and regulates SLC34A2 adaptation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SLC9A3R1 associates with SLC34A2 but not PDZK1
  • cell & other
    REGULATION
    inhibited by EGF
    ASSOCIATED DISORDERS
    corresponding disease(s) PLAM
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in breast and lung tumors
    tumoral     --over  
    in well-differentiated endometrioid and papillary serous ovarian carcinomas compared to low-differentiated endometrioid carcinomas, benign serous cystoadenomas and normal ovary
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • upregulation of SLC34A2 gene expression in well-differentiated tumors in ovarian cancerogenesis, and potential marker for ovarian cancer diagnosis and prognosis
  • Therapy target
    SystemTypeDisorderPubmed
    miscelleaneousurinarychronic kidney disease
    targeting SLC34A2 in addition to using dietary phosphorus binders may be a therapeutic approach to modulate serum phosphate in chronic kidney disease
    ANIMAL & CELL MODELS
  • homozygous NaPi-IIb deficient-mice died in utero soon after implantation, indicating that NaPi-IIb was essential for early embryonic development