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FLASH GENE
Symbol SLC30A8 contributors: /mct - updated : 14-04-2006
HGNC name solute carrier family 30 (zinc transporter), member 8
HGNC id 20303
Location 8q24.11      Physical location : 117.962.511 - 118.188.952
Synonym name zinc transporter ZnT-8
Synonym symbol(s) ZnT-8
DNA
TYPE functioning gene
STRUCTURE 41.62 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
TRPS1 8q24.11 trichorhinophalangeal syndrome I EIF3S3 8q24.13 eukaryotic translation initiation factor 3, subunit 3 gamma, 40kDa MGC14595 8q24.11 hypothetical protein MGC14595 RAD21 8q24.11 RAD21 homolog (S. pombe) SLC30A8 8q24.11 solute carrier family 30 (zinc transporter), member 8 TRAP25 EXT1 8q24.11 exostoses (multiple) 1 LOC392263 8 similar to RIKEN cDNA A830094I09 gene LOC286091 8q24.12 similar to 40S ribosomal protein S26 TNFRSF11B 8q24.13 tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) COLEC10 8q24.13 collectin sub-family member 10 (C-type lectin) MAL2 8q23 mal, T-cell differentiation protein 2 NOV 8q24.1 nephroblastoma overexpressed gene LOC392264 8 hypothetical gene supported by AK122835 ENPP2 8q24.13 ectonucleotide pyrophosphatase/phosphodiesterase 2 (autotaxin) HCP23 8q24.12 cytochrome c, somatic pseudogene TAF2 8q24.12 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa MGC5528 8q24.12 defective in sister chromatid cohesion homolog 1 (S. cerevisiae) MGC14407 8q24.12 hypothetical protein MGC14407 FLJ12428 8q24.12 hypothetical protein FLJ12428 LOC389682 8 similar to collagen type XIV COL14A1 8q24.13 collagen, type XIV, alpha 1 (undulin) MRPL13 8q22.1-q22.3 mitochondrial ribosomal protein L13 MTBP 8q24.1-q24.2 Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) binding protein, 104kDa SNTB1 8q24.13 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 5316 35 320 - -
- - 5561 35 320 - -
- - 5403 35 320 - -
- - 5430 35 320 - -
8 - 5373 40.6 369 - -
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinepancreas   specific
Nervousbraindiencephalonhypothalamus  
 brainforebraincerebral cortex  
Reproductivemale systemtestis   
Urinarykidney    
cells
SystemCellPubmedSpeciesStageRna symbol
Endocrineislet cell (alpha,beta...)
Reproductivespermatid
Reproductivespermatocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six transmembrane domains
  • a histidine-rich loop between transmembrane domains IV and V
  • HOMOLOGY
    Homologene
    FAMILY
  • cation diffusion facilitator (CDF) transporter family
  • SLC30A subfamily
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic,vesicle
    text in synaptic vesicles and in secretion vesicles membrane
    basic FUNCTION
  • involved in accumulation of zinc in synaptic vesicles
  • facilitating the accumulation of zinc from the cytoplasm into intracellular insulin-containing vesicles
  • involved in insulin maturation, storage and secretion (Cauchi 2010)
  • role in pancreatic islets (is particularly required for the normal accumulation of zinc in beta-cell granules) (Cauchi 2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta-cells
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to type 2 diabetes
    Variant & Polymorphism other
  • SLC30A8 rs13266634 polymorphism is among the most replicated genetic markers of T2D in Europeans and East Asian (Cauchi 2010)
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS