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FLASH GENE
Symbol SLC30A8 contributors: /mct - updated : 14-04-2006
HGNC name solute carrier family 30 (zinc transporter), member 8
HGNC id 20303
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinepancreas   specific
Nervousbraindiencephalonhypothalamus  
 brainforebraincerebral cortex  
Reproductivemale systemtestis   
Urinarykidney    
cells
SystemCellPubmedSpeciesStageRna symbol
Endocrineislet cell (alpha,beta...)
Reproductivespermatid
Reproductivespermatocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six transmembrane domains
  • a histidine-rich loop between transmembrane domains IV and V
  • HOMOLOGY
    Homologene
    FAMILY
  • cation diffusion facilitator (CDF) transporter family
  • SLC30A subfamily
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic,vesicle
    text in synaptic vesicles and in secretion vesicles membrane
    basic FUNCTION
  • involved in accumulation of zinc in synaptic vesicles
  • facilitating the accumulation of zinc from the cytoplasm into intracellular insulin-containing vesicles
  • involved in insulin maturation, storage and secretion (Cauchi 2010)
  • role in pancreatic islets (is particularly required for the normal accumulation of zinc in beta-cell granules) (Cauchi 2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta-cells
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to type 2 diabetes
    Variant & Polymorphism other
  • SLC30A8 rs13266634 polymorphism is among the most replicated genetic markers of T2D in Europeans and East Asian (Cauchi 2010)
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS