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FLASH GENE
Symbol SLC2A10 contributors: mct - updated : 06-04-2011
HGNC name solute carrier family 2 (facilitated glucose transporter), member 10
HGNC id 13444
Corresponding disease
ATS arterial tortuosity syndrome
Location 20q13.1      Physical location : 45.338.278 - 45.364.983
Synonym name sugar transporter GLUT10
Synonym symbol(s) GLUT10, GT10
DNA
TYPE functioning gene
SPECIAL FEATURE arranged in tandem
STRUCTURE 26.71 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
text structure
  • two major transcription start points with differential use in tissues and cell lines, harboring consensus binding sites for Sp, AP2alpha, and other transcription
  • a juxtaposed Sp/AP2alpha motif located between -25 and -11 is critical for core promoter function factors
  • a silencer region is present upstream of -696 which down-regulates SLC2A10 promoter activity independently of its distance to the transcript start site
  • MAPPING cloned Y linked N status provisional
    Physical map
    ZNF335 20q11.21-q13.12 zinc finger protein 335 FTLP 20q13.12 ferritin, light polypeptide pseudogene MMP9 20q11.2 matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) LOC128499 20q13.12 hypothetical LOC128499 SLC12A5 20q12-q13.1 solute carrier family 12, (potassium-chloride transporter) member 5 NCOA5 20q12-q13.2 nuclear receptor coactivator 5 RPL13P2 20q13.12 ribosomal protein L13 pseudogene 2 TNFRSF5 20q12-q13.2 tumor necrosis factor receptor superfamily, member 5 CDH22 20q12-q13.1 cadherin-like 22 SLC35C2 20q13.12 solute carrier family 35, member C2 ELMO2 20q13 engulfment and cell motility 2 (ced-12 homolog, C. elegans) DKFZp547G0215 20q13.12 hypothetical protein DKFZp547G0215 MKRNP3 20q21.1 makorin, ring finger protein, pseudogene 3 LOC343593 20q13.12 similar to BC331191_1 ZNF334 20q13.12 zinc finger protein 334 SLC13A3 20q12-q13.1 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 C20orf64 20q13 chromosome 20 open reading frame 64 SLC2A10 20q13.1 solute carrier family 2 (facilitated glucose transporter), member 10 EYA2 20q13.1 eyes absent homolog 2 (Drosophila) PRKCBP1 20q12-q13.1 protein kinase C binding protein 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 splicing 4394 56.9 541 - 2001 11247674
    - - splicing 1350 - - skeletal muscle 2001 11247674
    - - splicing 240 - - lung, liver 2001 11247674
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver    
    Endocrinepancreas    
     parathyroid   highly
    Reproductivefemale systembreastmammary gland highly
    Respiratoryrespiratory tracttrachea  highly
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    Muscularstriatumskeletal highly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    not specificadipocyte Homo sapiens
    Skin/Tegumentmelanocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • twelve putative transmembrane domains with a hydrophilic intracellular loop between helices 6 and 7
  • a large extracellular loop (containing a potential N linked glycosylation site) between helices 9 and 10
  • HOMOLOGY
    interspecies homolog to murine Slc2a10
    Homologene
    FAMILY solute carrier family 2, sugar transporter
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text localizes predominantly to the mitochondria of smooth muscle cells and insulin-stimulated adipocytes
    basic FUNCTION
  • playing a role in maintaining glucose homeostasis
  • may be transporting ascorbate, a cofactor for collagen and elastin hydroxylases, into the secretory pathway
  • facilitates transport of l-dehydroascorbic acid (DHA), the oxidized form of vitamin C, into mitochondria, and also increases cellular uptake of DHA, which in turn protects cells against oxidative stress
  • physiological role as the mitochondrial DHA transporter, and protects cells from oxidative injury
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS facilitated diffusion transport
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ATS
    Susceptibility to type 2 diabetes mellitus
    Variant & Polymorphism SNP associated with the risk of type 2 diabetes mellitus
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS