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FLASH GENE
Symbol SLC2A10 contributors: mct - updated : 23-03-2020
HGNC name solute carrier family 2 (facilitated glucose transporter), member 10
HGNC id 13444
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • twelve putative transmembrane domains with a hydrophilic intracellular loop between helices 6 and 7
  • a large extracellular loop (containing a potential N linked glycosylation site) between helices 9 and 10
    • HOMOLOGY
    interspecies homolog to murine Slc2a10
    Homologene
    FAMILY solute carrier family 2, sugar transporter
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text
  • localizes predominantly to the mitochondria of smooth muscle cells and insulin-stimulated adipocytes
  • 0 is present in the ER
  • targeting of SLC2A10 to mitochondria is important to maintain redox homeostasis, mitochondrial structure and mitochondrial function in arterial smooth muscle cells (ASMCS)
    • basic FUNCTION
  • playing a role in maintaining glucose homeostasis
  • may be transporting ascorbate, a cofactor for collagen and elastin hydroxylases, into the secretory pathway
  • evidence for SLC2A9 and SLC2A12 expression in vascular smooth muscle cells (VSMCs) in conjunction with the previously identified SLC2A1 and SLC2A10
  • facilitates transport of l-dehydroascorbic acid (DHA), the oxidized form of vitamin C, into mitochondria, and also increases cellular uptake of DHA, which in turn protects cells against oxidative stress
  • physiological role as the mitochondrial DHA transporter, and protects cells from oxidative injury
  • is essential for cardiovascular development by facilitating both mitochondrial respiration and TGFB1 signaling
  • facilitates dehydroascorbic acid transport
  • may have a role in maintaining the integrity of peripheral arteries
  • may contribute to glucose transport from the endolymph to the hair cells across the cuticular plate
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS facilitated diffusion transport
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ATS
    Susceptibility to type 2 diabetes mellitus
    Variant & Polymorphism SNP associated with the risk of type 2 diabetes mellitus
    Candidate gene
    Marker SLC2A5 with SLC2A10, and SLC2A13, are potential prognostic biomarkers in acute myeloid leukemia
    Therapy target
    ANIMAL & CELL MODELS