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FLASH GENE
Symbol SLC26A2 contributors: mct/npt - updated : 28-02-2014
HGNC name solute carrier family 26 (sulfate transporter), member 2
HGNC id 10994
Corresponding disease
ACG1B achondrogenesis IB
ATSG2 atelosteogenesis, type II
DTD diastrophic dysplasia
EDM4 epiphyseal dysplasia multiple 4
Location 5q33.1      Physical location : 149.340.299 - 149.366.959
Synonym name
  • diastrophic dysplasia sulfate transporter
  • sulfate anion transporter 1
  • Synonym symbol(s) DTDST, MST153, D5S1708, MSTP157, DTD
    DNA
    TYPE functioning gene
    STRUCTURE 26.66 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Map cen - D5S413 - SLC26A2 - D5S2015 - D5S2013 - qter
    Authors UCSC (2009)
    Physical map
    ADRB2 5q31.3 adrenergic, beta-2-, receptor, surface KIAA1985 LOC255187 5q33.1 hypothetical LOC255187 KIAA0843 FLJ36748 5q33.1 hypothetical protein FLJ36748 GRPEL2 5q33.1 GrpE-like 2, mitochondrial (E. coli) MGC3265 5q33.1 hypothetical protein MGC3265 IL17B 5q32-34 interleukin 17B CSNK1A1 13q13 casein kinase 1, alpha 1 LOC389337 5 similar to hypothetical protein 4933429F08 PERC 5q33.1 similar to hypothetical protein 4933429F08 PDE6A 5q31.3 phosphodiesterase 6A, cGMP-specific, rod, alpha SLC26A2 5q31.3 solute carrier family 26 (sulfate transporter), member 2 TIGD6 5q32 tigger transposable element derived 6 RPS20P4 5q33-qter ribosomal protein S20 pseudogene 4 CSF1R 5q31.3 colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog RPL7P 5q33.3 ribosomal protein L7 pseudogene PDGFRB 5q31.3 platelet-derived growth factor receptor, beta polypeptide CDX1 5q31.3 caudal type homeo box transcription factor 1 SLC6A7 5q31-q32 solute carrier family 6 (neurotransmitter transporter, L-proline), member 7 CAMK2A 5q33.2 calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha LOC340075 5q33.1 similar to RIKEN cDNA 9330196J05 TCOF1 5q32-q33.1 Treacher Collins-Franceschetti syndrome 1 CD74 5q31.3 CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) RPS14 5q32 ribosomal protein S14 NDST1 5q31.3-q32 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 SYNPO 5q33.1 synaptopodin MYOZ3 5q33.1 myozenin 3 FLJ10290 5q33.1 hypothetical protein FLJ10290 DCTN4 5q31-q32 dynactin 4 (p62) NID67 5q33.1 putative small membrane protein NID67 LRG47 5q33.1 LRG-47-like protein ZNF300 21 zinc finger protein 300 GPX3 5q23 glutathione peroxidase 3 (plasma) TNIP1 5q32-q33.1 TNFAIP3 interacting protein 1 ANXA6 5q32 annexin A6 DKFZP434C171 5q33.1 DKFZP434C171 protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 8082 81.5 739 - 1998 9822202
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon   Homo sapiens
     salivary gland   highly Homo sapiens
    Endocrinepancreas   highly Homo sapiens
    Reproductivefemale systemplacenta    Homo sapiens
    Respiratoryrespiratory tracttrachea  highly Homo sapiens
    Urinarykidneytubuleconvoluted tubuleproximal tubule  Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivecartilage  highly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestiveepithelial cell Homo sapiens
    not specificchondrocyte Homo sapiens
    Respiratoryepithelial cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    Text
  • most abundant sulfate transporter mRNAs, which localized to cytotrophoblast cells(
  • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N- and C-cytoplasmic termini
  • twelve transmembrane segments (12TM)
  • a large cytoplasmic tail with a sulfate transporter motif
  • a relatively hydrophobic region near the C terminus, the STAS domain (sulfate transporter and anti-sigma factor antagonist)
  • conjugated GlycoP , PhosphoP
    HOMOLOGY
    interspecies homolog to rattus Slc26a2 (81.1 pc)
    homolog to murine Slc26a2 (80.9 pc)
    Homologene
    FAMILY
  • anion exchanger family
  • SLC26A/SULP transporter family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in proteoglycan sulfate activation
  • may play a role in endochondral bone formation
  • functions as an electroneutral SO42&
  • 8722;/OH&
    8722;(H+)/Cl&
    8722; exchanger
  • physiological roles for SLC13A4 and SLC26A2 in human placental sulfate transport
  • multiple roles in chondrocyte biology and importance of SLC26A2-mediated protein sulfation in cell signaling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport
    text Na+ independent sulfate transporter
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other regulation of SLC26A2 by an extracellular anion binding site
    ASSOCIATED DISORDERS
    corresponding disease(s) ACG1B , ATSG2 , DTD , EDM4
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Nephrolithiasis in the Slc26a6(-/-) mouse is accompanied by 50-75p100 reduction in intestinal oxalate secretion with unchanged intestinal oxalate absorption
  • collagen fibrils in bone were thinner and less organized in dtd compared to wild-type mice, suggesting that the low bone mass observed in mutant mice could possibly be linked to the different bone matrix compositions/organizations in dtd mice triggering changes in osteoblast and osteoclast activities