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FLASH GENE
Symbol SLC26A2 contributors: mct/npt - updated : 28-02-2014
HGNC name solute carrier family 26 (sulfate transporter), member 2
HGNC id 10994
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon   Homo sapiens
 salivary gland   highly Homo sapiens
Endocrinepancreas   highly Homo sapiens
Reproductivefemale systemplacenta    Homo sapiens
Respiratoryrespiratory tracttrachea  highly Homo sapiens
Urinarykidneytubuleconvoluted tubuleproximal tubule  Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivecartilage  highly Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Digestiveepithelial cell Homo sapiens
not specificchondrocyte Homo sapiens
Respiratoryepithelial cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
Text
  • most abundant sulfate transporter mRNAs, which localized to cytotrophoblast cells(
  • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N- and C-cytoplasmic termini
  • twelve transmembrane segments (12TM)
  • a large cytoplasmic tail with a sulfate transporter motif
  • a relatively hydrophobic region near the C terminus, the STAS domain (sulfate transporter and anti-sigma factor antagonist)
  • conjugated GlycoP , PhosphoP
    HOMOLOGY
    interspecies homolog to rattus Slc26a2 (81.1 pc)
    homolog to murine Slc26a2 (80.9 pc)
    Homologene
    FAMILY
  • anion exchanger family
  • SLC26A/SULP transporter family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in proteoglycan sulfate activation
  • may play a role in endochondral bone formation
  • functions as an electroneutral SO42&
  • 8722;/OH&
    8722;(H+)/Cl&
    8722; exchanger
  • physiological roles for SLC13A4 and SLC26A2 in human placental sulfate transport
  • multiple roles in chondrocyte biology and importance of SLC26A2-mediated protein sulfation in cell signaling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport
    text Na+ independent sulfate transporter
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other regulation of SLC26A2 by an extracellular anion binding site
    ASSOCIATED DISORDERS
    corresponding disease(s) ACG1B , ATSG2 , DTD , EDM4
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Nephrolithiasis in the Slc26a6(-/-) mouse is accompanied by 50-75p100 reduction in intestinal oxalate secretion with unchanged intestinal oxalate absorption
  • collagen fibrils in bone were thinner and less organized in dtd compared to wild-type mice, suggesting that the low bone mass observed in mutant mice could possibly be linked to the different bone matrix compositions/organizations in dtd mice triggering changes in osteoblast and osteoclast activities