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Symbol SLC25A5 contributors: mct - updated : 22-05-2013
HGNC name solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
HGNC id 10991
Corresponding disease
HARTS Hartsfield syndrome
Location Xq24      Physical location : 118.602.362 - 118.605.357
Synonym name
  • solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5,(?unlikely to be EFE locus)
  • ADP/ATP translocator of fibroblasts
  • adenine nucleotide translocase-2
  • ADP/ATP translocase 2
  • Synonym symbol(s) ANT2, T3, ADT2, 2F1, AAC2, T2
    TYPE functioning gene
    STRUCTURE 2.99 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter (TATA box)
    Binding site   silencer
    text structure Sp1activating element and an upstream silencer
    MAPPING cloned Y linked N status confirmed
    Map cen - DXS1072 - DXS19 - DXS424 - DXS37 - SLC25A5 - DXS1212 - DXS42 - qter
    Authors Schiebel (94), Consensus (95)
    Physical map
    LOC392528 X similar to beta-tubulin 1 DKFZp686L20145 Xq24 similar to rab11-binding protein LOC389882 X LOC389882 DOCK11 Xq24 dedicator of cytokinesis 11 IL13RA1 Xq22-q26 interleukin 13 receptor, alpha 1 LOC170261 Xq24 hypothetical protein LOC170261 LOC159007 Xq24 similar to Aflatoxin B1 aldehyde reductase member 2 (AFB1-AR 1) (Aldoketoreductase 7) LOC392529 X hypothetical gene supported by NM_015198 RNF127 Xq24 ring finger protein 127 KIAA1210 Xq24 KIAA1210 protein LOC389883 X similar to Hnrpa1 protein PGRMC1 Xq22-q24 progesterone receptor membrane component 1 LOC139516 Xq24 similar to DNA segment on chromosome X and Y (unique) 155 expressed sequence; Pseudoautosomal gene XE7 (Y chromosome) MRPS17P9 Xq24 similar to DNA segment on chromosome X and Y (unique) 155 expressed sequence; Pseudoautosomal gene XE7 (Y chromosome) LOC203427 Xq24 similar to solute carrier family 25 , member 16 SLC25A5 Xq24-q26 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 FLJ22965 Xq23 hypothetical protein FLJ22965 UBE2A Xq24-q25 ubiquitin-conjugating enzyme E2A (RAD6 homolog) NRF Xq24-q25 ubiquitin-conjugating enzyme E2A (RAD6 homolog) SEPT6 Xq24 ubiquitin-conjugating enzyme E2A (RAD6 homolog) LOC347454 Xq25 similar to hypothetical protein A630014H24 RPL39 Xq22.1-q22.2 ribosomal protein L39 LOC158796 Xq25 similar to UPF3 regulator of nonsense transcripts homolog B isoform 2 UPF3B Xq25-q26 UPF3 regulator of nonsense transcripts homolog B (yeast) ZNF183 Xq24-q25 zinc finger protein 183 (RING finger, C3HC4 type) NDUFA1 Xq24 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa AKAP28 Xq25 A-kinase anchor protein 28 NKAP Xq25 NF-kappaB activating protein OTEX Xq25 paired-like homeobox protein OTEX LOC392530 X similar to hypothetical protein FLJ22626 PEPP-2 Xq25 PEPP subfamily gene 2 LOC340576 Xq25 similar to eukaryotic translation elongation factor 1 alpha 1; CTCL tumor antigen; translation elongation factor 1 alpha 1-like 14; prostate tumor-inducing protein 1; EF1a-like protein; glucocorticoid receptor AF-1 specific elongati FLJ36576 Xq25 hypothetical protein FLJ36576 ZNF-kaiso Xq23 kaiso FLJ20716 Xq25 hypothetical protein FLJ20716 ATP1B4 Xq24 ATPase, (Na+)/K+ transporting, beta 4 polypeptide LAMP2 Xq24 lysosomal-associated membrane protein 2 RNU7P1 Xq25 RNA, U7 small nuclear pseudogene 1 RNU7P2 Xq25 RNA, U7 small nuclear pseudogene 2 CUL4B Xq23 cullin 4B MCTS1 Xq22-24 malignant T cell amplified sequence 1 C1GALT2 Xq25 core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 2 LOC392531 X similar to RIKEN cDNA 2900070E19
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1351 - 298 - 2010 19763879
    Type ubiquitous
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver     Homo sapiensAdultmRNA
    Nervousbrainlimbic systemhippocampus highly Homo sapiens
     brainforebraincerebral cortex highly Homo sapiens
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadiposebrown   Homo sapiensAdultmRNA
    cell lineage
    cell lines
    at STAGE
    three tandemly repeated mitochondrial carrier protein domains (SOLCAR repeats)
    mono polymer homomer , dimer
    interspecies homolog to murine Slc25a5
    FAMILY solute carrier family 25, mitochondrial, adenine nucleotide
    CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
  • imports glycolytically produced ATP into the mitochondria
  • basic FUNCTION
  • ADP/ATP translocase, oxidative phosphorylation (OXPHOS), catalyzing the exchange of ADP and ATP across the mitochondrial inner membrane
  • playing an important role in maintaining the cytosolic phosphorylation potential required for cell growth
  • linked to the rate of glycolytic metabolism, is an important indicator of carcinogenesis
  • not pro-apoptotic and may therefore contribute to carcinogenesis
  • is involved in memory formation or establishment, which could add mitochondrial processes to the wide array of pathways that regulate normal cognitive functions
  • CELLULAR PROCESS cell cycle, progression
    PHYSIOLOGICAL PROCESS mitochondrial transport
    text energy transfer
    metabolism energetic , metal
    a component
  • complexing with cyclophilin D (PPID and PPIF) at the inner mitochondrial membrane and voltage dependent anion selective channel(s) at the outer membrane, to form the mitochondrial permeability transition pore
    small molecule
  • NF1 (nuclear factor 1) binds to two upstream elements of SLC25A5 promoter and actively represses expression of the gene in growth-arrested diploid skin fibroblasts
  • interacts with Fe-S apoproteins and MMS19 in the cytosolic Fe-S cluster assembly complex but not with the individual proteins
  • cell & other
    repressed by nuclear factor-1 in growth-arrested human diploid cells
    corresponding disease(s) HARTS
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   deletion    
    in patients with non-syndromic ntellectual disability (ID) plus some additional features
    Variant & Polymorphism
    Candidate gene
  • candidate for cancer therapy based on molecular targeting
  • Marker
    Therapy target