Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SLC25A32 contributors: mct - updated : 18-03-2024
HGNC name solute carrier family 25, member 32
HGNC id 29683
Corresponding disease
RREI Riboflavin-Responsive Exercise Intolerance
Location 8q22.3      Physical location : 104.410.866 - 104.427.468
Genatlas name mitochondrial folate transporter/carrier
Synonym name
  • Glycine auxotroph B, complementation of hamster
  • glycine B complementing
  • mitochondrial FAD transporter
    • Synonym symbol(s) MFTC, MFT, GLYB, RREI, FLJ23872
    DNA
    TYPE functioning gene
    STRUCTURE 16.47 kb     7 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 2891 - 315 - 2022 35727412
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveintestinelarge intestinecolon  
    Lymphoid/Immunelymph node    
     spleen    
    Nervousbrain    
    Reproductivefemale systembreastmammary gland highly
    Respiratorylung    
     respiratory tractlarynx   
    Skin/Tegumentskin   highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    		three Solcar repeats
    HOMOLOGY
    interspecies homolog to S. cerevisiae Flx1
    Homologene
    FAMILY mitochondrial carrier family
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • transporting folate across the inner membranes of mitochondria
  • mitochondrial FAD transporter
  • transports tetrahydrofolate (THF) as well as FAD into mitochondria and regulates mitochondrial one-carbon metabolism and redox balance
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • sustains cancer cell proliferation by regulating flavin adenine nucleotide (FAD) metabolism
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) RREI
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Slc25a32 -/- mice die in utero with neural tube defects (NTDs)