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FLASH GENE
Symbol SLC25A32 contributors: mct - updated : 18-03-2024
HGNC name solute carrier family 25, member 32
HGNC id 29683
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 2891 - 315 - 2022 35727412
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveintestinelarge intestinecolon  
Lymphoid/Immunelymph node    
 spleen    
Nervousbrain    
Reproductivefemale systembreastmammary gland highly
Respiratorylung    
 respiratory tractlarynx   
Skin/Tegumentskin   highly
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
three Solcar repeats
HOMOLOGY
interspecies homolog to S. cerevisiae Flx1
Homologene
FAMILY mitochondrial carrier family
CATEGORY transport carrier
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria,inner
intracellular,cytoplasm,organelle,membrane
basic FUNCTION
  • transporting folate across the inner membranes of mitochondria
  • mitochondrial FAD transporter
  • transports tetrahydrofolate (THF) as well as FAD into mitochondria and regulates mitochondrial one-carbon metabolism and redox balance
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • sustains cancer cell proliferation by regulating flavin adenine nucleotide (FAD) metabolism
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) RREI
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Slc25a32 -/- mice die in utero with neural tube defects (NTDs)