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FLASH GENE

Symbol

SLC22A16

contributors: mct/npt - updated : 30-04-2010

HGNC name	solute carrier family 22 (organic cation/carnitine transporter), member 16
HGNC id	20302

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	MAFD17 manic depressive illness 17
Location	6q21      Physical location : 110.745.906 - 110.797.844
Synonym name	solute carrier family 22 (organic cation transporter), member 16
	organic cation transporter 6
	fly-like putative organic ion transporter 2
	carnitine transporter 2
Synonym symbol(s)	CT2, OCT6, OKB1, FLIPT2, WUGSC:RG331P03.1, dJ261K5.1

DNA

TYPE	functioning gene
STRUCTURE	51.94 kb     8 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_033125 8 - 1983 NP_149116 - 577 - Aouida (2010)

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune spleen       lowly Nervous brain hindbrain medulla oblongata   lowly Reproductive male system male genital tract epididymis   predominantly   male system testis     specific Visual eye lacrimal gland     lowly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     highly

cells

System Cell Pubmed Species Stage Rna symbol Reproductive epididymal cell Reproductive spermatozoa

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	all fetal tissues

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	twelve transmembrane domains
	several sites for N-glycosylation and phosphorylation

HOMOLOGY

Homologene

FAMILY	major facilitator superfamily
	organic cation transporter family
	sugar transporter family

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION	plasma membrane
text	in the luminal membrane of epididymal epithelium and within the Sertoli cells of the testis

basic FUNCTION	playing a role in the transport of carnitine in the epididymal epithelium and in the maturation of spermatozoa
	organic cation transporter, mediator of doxorubicin uptake in cancer cells
	involved in bleomycin-A5 uptake, as well as polyamines, (Aouida 2010)
	may be functioning as a polyamine:l-carnitine antiporter by exporting polyamines in exchange for l-carnitine during sperm capacitation (Aouida 2010)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

carbohydrate

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

MAFD17

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in endometrium during the normal secretory phase, but its level was significantly reduced in the proliferative phase tumoral     --over   in endometrial cancer in the presence of progesterone tumoral     --over   in testicular cancer cells (Aouida 2010)

Susceptibility

for bipolar disorder type I

Variant & Polymorphism

Candidate gene
Marker
Therapy target	use progestins to increase the response of endometrioid endometrial carcinoma with SLC22A16 expression to adriamycin-based chemotherapeutic regimens

ANIMAL & CELL MODELS