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Symbol SIN3A contributors: mct/npt/pgu - updated : 01-02-2017
HGNC name SIN3 homolog A, transcriptional regulator (yeast)
HGNC id 19353
Location 15q24.2      Physical location : 75.661.721 - 75.748.124
Synonym name
  • histone deacetylase complex subunit Sin3a
  • transcriptional co-repressor Sin3A
  • paired amphipathic helix protein Sin3a
  • Synonym symbol(s) KIAA0700, DKFZP434K2235, mSIN3A, FLJ90319, SIN3
    TYPE functioning gene
    STRUCTURE 86.44 kb     21 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map see TM6SF1
    Physical map
    FLJ32855 15q23 hypothetical protein FLJ32855 CYP11A1 15q23-q24 cytochrome P450, family 11, subfamily A, polypeptide 1 SEMA7A 15q22.3-q23 sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A MGC14421 DRIL2 15q24 sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A CLK3 15q24 CDC-like kinase 3 FLJ21128 15q23 hypothetical protein FLJ21128 CYP1A1 15q22-q24 cytochrome P450, family 1, subfamily A, polypeptide 1 CYP1A2 15q22-q24 cytochrome P450, family 1, subfamily A, polypeptide 2 CSK 15q23-q25 c-src tyrosine kinase LMAN1L 15q22-23 lectin, mannose-binding, 1 like DKFZP434C131 15q23 DKFZP434C131 protein SCAMP2 15q23-q25 secretory carrier membrane protein 2 MPI 15q22-qter mannose phosphate isomerase FLJ00005 COX5A 15q25 cytochrome c oxidase subunit Va Rpp25 15q23 RNase P protein subunit p25 SCAMP5 15q22.33 RNase P protein subunit p25 MDS018 15q23 hypothetical protein MDS018 LOC390605 15 similar to stromal cell-derived factor 2 precursor DKFZP434H132 15q23 DKFZP434H132 protein LOC390606 15 similar to nucleolar phosphoprotein Nopp34 LOC388136 15 LOC388136 LOC388137 15 similar to Golgi autoantigen, golgin subfamily A member 6 (Golgin linked to PML) (Golgin-like protein) LOC390607 15 similar to Dynamin-1 (D100) (Dynamin, brain) (B-dynamin) LOC145801 15q23 similar to Acidic leucine-rich nuclear phosphoprotein 32 family member B (PHAPI2 protein) (Silver-stainable protein SSP29) (Acidic protein rich in leucines) FLJ20452 15q23 hypothetical protein FLJ20452 NEIL1 15q23 nei endonuclease VIII-like 1 (E. coli) MAN2C1 15q11-q13 mannosidase, alpha, class 2C, member 1 SIN3A 15q24 SIN3 homolog A, transcriptional regulator (yeast) PTPN9 15q22.33 protein tyrosine phosphatase, non-receptor type 9 RNUT1 15q22.33 RNA, U transporter 1 C15orf12 15q24 chromosome 15 open reading frame 12 MGC32065 15q23 hypothetical protein MGC32065 CSPG4 15q23 chondroitin sulfate proteoglycan 4 (melanoma-associated) MGC48986 15q23 hypothetical protein MGC48986 LOC388138 15 similar to Dynamin-1 (D100) (Dynamin, brain) (B-dynamin) LOC390608 15 similar to peptidyl-Pro cis trans isomerase LOC390609 15 similar to Golgi autoantigen, golgin subfamily A member 6 (Golgin linked to PML) (Golgin-like protein) LOC92912 15q23 hypothetical protein LOC92912 FBXO22 15q24.1 F-box only protein 22 LOC145957 15q23 neuregulin 4 FLJ38190 15q23-q24.1 hypothetical protein FLJ38190 ETFA 15q23-q25 electron-transfer-flavoprotein, alpha polypeptide (glutaric aciduria II)
    TRANSCRIPTS type messenger
    text Variants 1, 2 and 3 encode the same protein
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    21 - 6697 145 1273 - 1995 7889570
    21 - 6795 145 1273 - 1995 7889570
    21 - 6620 145 1273 - 1995 7889570
    Type widely
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue  highly
    Lymphoid/Immunethymus   highly
    Reproductivefemale systembreastmammary gland highly
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cell lineage
    cell lines
    at STAGE
    PHYSICAL PROPERTIES acid Amphiphilic
  • four PAH (paired amphipathic helix) motifs, PAH3 interacting with SAP30
  • a poly-proline, a poly-alanine-glutamine and acidic regions
  • conjugated GlycoP
    interspecies ortholog to murine Sin3a
    ortholog to rattus Sin3a predicted
    intraspecies paralog to SIN3B
    CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • mediating repression by the Mad-Max complex
  • transcriptional role for SIN3A and SIN3B proteins associated with maintenance of differentiated muscle cells
  • SIN3A and SIN3B regulate gene expression at the chromatin-level by serving as an anchor onto which the core SIN3/HDAC complex is assembled
  • is an important mediator of the STAT3-targeted transcriptional repression
  • critical role for the SIN3A complex in balancing STAT functions at the transcriptional level
  • unique role for the SIN3A complex as a negative regulator of STAT3 transcriptional activity, regardless of the activating stimulus
  • exerting opposite regulation on STAT3 and ISGF3-dependent transcription, SIN3A represents a unique control level determining cytokine-specific responses in different tissues or cells
  • within the male germline, SIN3A is required for the mitotic reentry of gonocytes, but is dispensable for the maintenance of differentiating spermatogonia and subsequent spermatogenic processes
  • is a key buffer controlling muscle responsiveness to transcription factors in the formation of muscle identity, thereby generating tissue diversity
  • metastasis suppressive roles of SIN3A and metastasis promoting roles of SIN3B in breast cancer
  • corepressor SIN3A controls histone acetylation through association with the histone deacetylase RPD3
  • is an important epigenetic regulator directly connecting methionine metabolism and histone modification
  • CELLULAR PROCESS nucleotide, transcription, regulation
    text transcription co-repressor
    a component
  • methylglyoxal modification
  • part of an MORF4L1/PHF12/SIN3A complex may be implicated in the unique functions of MORF4L1
  • SIN3A complex acts as a context-dependent ISGF3/STAT3 transcriptional switch
    DNA binding
    small molecule
  • interacting with NFX1 (NFX1-91 interacts with the corepressor complex SIN3A/histone deacetylase (HDAC) at the TERT promoter)
  • ING2 binding to the SIN3A complex may be enhanced by sumoylation of ING2
  • interacting with SAP30 and forming a SIN3A PAH3-SAP30 SID complex that can bind to nucleic acids
  • SIN3A coupled with MECP2 bound to the GFAP promoter and their occupancies were correlated with repression of GFAP transcription
  • FOXK1 interacts with SIN3A/SIN3B through the SID and SIN3A/SIN3B has an important role in the regulation of cell cycle kinetics of the myogenic progenitors cells population
  • directly interacts with STAT3 and promotes its deacetylation
  • FAM60A promotes the retention of HDAC1 but not SIN3A at the CCND1 promoter in asynchronously growing cells
  • PHF12 interacts directly with SIN3A, which in turn interacts with SNAI2, resulting in recruitment of the HDAC complex to the promoter region of CDH6
  • SIN3A-associated HDAC1/2-activity is essential for hematopoietic stem cell homeostasis
  • SIN3A physically interacts with the CYP1A1 gene and extends the transcriptional role of SIN3A to a gene that is very rapidly and dramatically induced
  • catalytic domain of TET3 interacts with HDAC1 and SIN3A, thus enhancing their binding to the IFNB1 promoter
  • cell & other