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FLASH GENE
Symbol SIN3A contributors: mct/npt/pgu - updated : 01-02-2017
HGNC name SIN3 homolog A, transcriptional regulator (yeast)
HGNC id 19353
DNA
TYPE functioning gene
STRUCTURE 86.44 kb     21 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map see TM6SF1
RNA
TRANSCRIPTS type messenger
text Variants 1, 2 and 3 encode the same protein
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
21 - 6697 145 1273 - 1995 7889570
21 - 6795 145 1273 - 1995 7889570
21 - 6620 145 1273 - 1995 7889570
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtongue  highly
Lymphoid/Immunethymus   highly
Reproductivefemale systembreastmammary gland highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES acid Amphiphilic
STRUCTURE
motifs/domains
  • four PAH (paired amphipathic helix) motifs, PAH3 interacting with SAP30
  • a poly-proline, a poly-alanine-glutamine and acidic regions
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Sin3a
    ortholog to rattus Sin3a predicted
    intraspecies paralog to SIN3B
    Homologene
    FAMILY
    CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome,kinetochore
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • mediating repression by the Mad-Max complex
  • transcriptional role for SIN3A and SIN3B proteins associated with maintenance of differentiated muscle cells
  • SIN3A and SIN3B regulate gene expression at the chromatin-level by serving as an anchor onto which the core SIN3/HDAC complex is assembled
  • is an important mediator of the STAT3-targeted transcriptional repression
  • critical role for the SIN3A complex in balancing STAT functions at the transcriptional level
  • unique role for the SIN3A complex as a negative regulator of STAT3 transcriptional activity, regardless of the activating stimulus
  • exerting opposite regulation on STAT3 and ISGF3-dependent transcription, SIN3A represents a unique control level determining cytokine-specific responses in different tissues or cells
  • within the male germline, SIN3A is required for the mitotic reentry of gonocytes, but is dispensable for the maintenance of differentiating spermatogonia and subsequent spermatogenic processes
  • is a key buffer controlling muscle responsiveness to transcription factors in the formation of muscle identity, thereby generating tissue diversity
  • metastasis suppressive roles of SIN3A and metastasis promoting roles of SIN3B in breast cancer
  • corepressor SIN3A controls histone acetylation through association with the histone deacetylase RPD3
  • is an important epigenetic regulator directly connecting methionine metabolism and histone modification
  • SIN3A and SIN3B contribute likely to repressor function of enhancers and promoters in peripheral blood mononuclear cells (PBMCs)
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    text transcription co-repressor
    PATHWAY
    metabolism
    signaling
    a component
  • methylglyoxal modification
  • part of an MORF4L1/PHF12/SIN3A complex may be implicated in the unique functions of MORF4L1
  • SIN3A complex acts as a context-dependent ISGF3/STAT3 transcriptional switch
  • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • interacting with NFX1 (NFX1-91 interacts with the corepressor complex SIN3A/histone deacetylase (HDAC) at the TERT promoter)
  • ING2 binding to the SIN3A complex may be enhanced by sumoylation of ING2
  • interacting with SAP30 and forming a SIN3A PAH3-SAP30 SID complex that can bind to nucleic acids
  • SIN3A coupled with MECP2 bound to the GFAP promoter and their occupancies were correlated with repression of GFAP transcription
  • FOXK1 interacts with SIN3A/SIN3B through the SID and SIN3A/SIN3B has an important role in the regulation of cell cycle kinetics of the myogenic progenitors cells population
  • directly interacts with STAT3 and promotes its deacetylation
  • FAM60A promotes the retention of HDAC1 but not SIN3A at the CCND1 promoter in asynchronously growing cells
  • PHF12 interacts directly with SIN3A, which in turn interacts with SNAI2, resulting in recruitment of the HDAC complex to the promoter region of CDH6
  • SIN3A-associated HDAC1/2-activity is essential for hematopoietic stem cell homeostasis
  • SIN3A physically interacts with the CYP1A1 gene and extends the transcriptional role of SIN3A to a gene that is very rapidly and dramatically induced
  • catalytic domain of TET3 interacts with HDAC1 and SIN3A, thus enhancing their binding to the IFNB1 promoter
  • TET1 is found to recruit the co-repressor proteins, SIN3A and the histone lysine methyltransferase, EZH2 to osteogenic genes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS