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FLASH GENE
Symbol SHC3 contributors: - updated : 20-10-2004
HGNC name src homology 2 domain containing transforming protein C3
HGNC id 18181
Location 9q22.1      Physical location : 91.620.685 - 91.793.682
Synonym name neuronal Shc
Synonym symbol(s) NSHC, SHCC
DNA
TYPE functioning gene
STRUCTURE 165.00 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
GAS1 9q21.3-q22.1 growth arrest-specific 1 LOC157956 9q22.1 cell division cycle 20 pseudogene LOC392359 9 similar to transactivator HSM-1 DAPK1 9q34.1 death-associated protein kinase 1 CTSL 9q21-q22 cathepsin L LOC392360 9 similar to Eukaryotic translation initiation factor 3 subunit 1 (eIF-3 alpha) (eIF3 p35) (eIF3j) LOC392361 9 similar to Cathepsin L precursor (Major excreted protein) (MEP) LOC392362 9 similar to fructose-1,6-bisphosphatase 2; fructose-1,6-bisphosphatase isozyme 2; D-fructose-1,6-bisphosphate 1-phosphohydrolase; FBPase; muscle fructose-bisphosphatase; hexosediphosphatase LOC392363 9 similar to Cathepsin L precursor (Major excreted protein) (MEP) LOC392364 9 similar to chromosome 15 open reading frame 2 FLJ35866 LOC286235 9q22.2 hypothetical protein LOC286235 CCRK 9q22.2 cell cycle related kinase LOC158104 9q22.2 similar to 40S ribosomal protein S10 LOC389767 9 LOC389767 DKFZP434M131 9q22.1 DKFZP434M131 protein LOC389768 9 similar to potassium channel tetramerisation domain containing 1; chromosome 18 open reading frame 5 LOC389769 9 similar to Laminin receptor 1 SPIN 9q22.1-q22.3 spindlin LOC158046 9q22.2 similar to hypothetical protein BC014127 EDG3 9q22.1-q22.2 endothelial differentiation, sphingolipid G-protein-coupled receptor, 3 SHC3 9q22.1 src homology 2 domain containing transforming protein C3 CKS2 9q22 CDC28 protein kinase regulatory subunit 2 SBP2 9q22.2 SECIS binding protein 2 GADD45G 9q22.1-q22.2 growth arrest and DNA-damage-inducible, gamma LOC389770 9 similar to QCWQ6494 LOC389771 9 LOC389771 LOC157916 9q22.31 interleukin 6 receptor pseudogene LOC392365 9 similar to putative taste receptor HTR2 LOC392366 9 similar to seven transmembrane helix receptor DIRAS2 9q22.32 DIRAS family, GTP-binding RAS-like 2 LOC392367 9 similar to putative taste receptor HTR2 LOC283493 9q22.31 similar to seven transmembrane helix receptor SYK 9q22.1-q22.3 spleen tyrosine kinase
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainforebraincerebral cortex highly
 brainhindbrainmedulla oblongata lowly
 brainhindbraincerebellum lowly
 braindiencephalonthalamus lowly
 braindiencephalonhypothalamus lowly
 braindiencephalonamygdala highly
 brainbasal nucleiputamen lowly
 brainbasal nucleicorpus callosum lowly
 brainbasal nucleicaudate nucleus highly
 brainmidbrainsubstantia nigra lowly
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron
cell lineage
cell lines SK-N-BE(2) neuroblastoma
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a phosphotyrosine interaction (PTB/PID) domain
  • a CH1 region containing tyrosine phosphorylation sites and putative SH3-binding sites
  • a Src homology 2 (SH2) domain
  • HOMOLOGY
    interspecies homolog to murine Shc3
    homolog to rattus Shc3
    Homologene
    FAMILY Shc family
    CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • involved in the nerve-growth factor signaling through its binding to activated tyrosine kinase receptors
  • inhibits apoptosis by coupling Ret to the PI3K/Akt signaling pathway
  • its activation might give additional effects on malignant tumor progression of neuroblastoma
  • mediates neurotrophin and other neuronal signalings in the central nervous system
  • CELLULAR PROCESS cell life, antiapoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to GRB2
  • interacting with activated EGF receptors
  • interacting with beta-amyloid precursor protein
  • cell & other
    REGULATION
    activated by Ret
    Other tyrosine phosphorylated
    potent substrate of the activated Akt kinase
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS