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FLASH GENE
Symbol SHC3 contributors: - updated : 20-10-2004
HGNC name src homology 2 domain containing transforming protein C3
HGNC id 18181
DNA
TYPE functioning gene
STRUCTURE 165.00 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainforebraincerebral cortex highly
 brainhindbrainmedulla oblongata lowly
 brainhindbraincerebellum lowly
 braindiencephalonthalamus lowly
 braindiencephalonhypothalamus lowly
 braindiencephalonamygdala highly
 brainbasal nucleiputamen lowly
 brainbasal nucleicorpus callosum lowly
 brainbasal nucleicaudate nucleus highly
 brainmidbrainsubstantia nigra lowly
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron
cell lineage
cell lines SK-N-BE(2) neuroblastoma
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a phosphotyrosine interaction (PTB/PID) domain
  • a CH1 region containing tyrosine phosphorylation sites and putative SH3-binding sites
  • a Src homology 2 (SH2) domain
  • HOMOLOGY
    interspecies homolog to murine Shc3
    homolog to rattus Shc3
    Homologene
    FAMILY Shc family
    CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • involved in the nerve-growth factor signaling through its binding to activated tyrosine kinase receptors
  • inhibits apoptosis by coupling Ret to the PI3K/Akt signaling pathway
  • its activation might give additional effects on malignant tumor progression of neuroblastoma
  • mediates neurotrophin and other neuronal signalings in the central nervous system
  • CELLULAR PROCESS cell life, antiapoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to GRB2
  • interacting with activated EGF receptors
  • interacting with beta-amyloid precursor protein
  • cell & other
    REGULATION
    activated by Ret
    Other tyrosine phosphorylated
    potent substrate of the activated Akt kinase
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS