basic FUNCTION
| molecular scaffold in the postsynaptic density |
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regulate the size and shape of dendritic spines because of their capacity to directly interact with many different PSD components and represent master scaffold proteins of the PSD (Schutt 2009) |
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could play a critical role in the neuronal differentiation of the developing retina (Kim 2009) |
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scaffolding molecule of the postsynaptic density (PSD) of excitatory synapses, which is crucial for postsynaptic density (PSD) assembly and the formation of dendritic spines |
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concerted action of SHANK2 and Zn(2+) is essential for the structural integrity of postsynaptic density (PSD) and moreover that it is an important element of synapse formation, maturation and structural plasticity |
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is likely involved in the initial steps of postsynaptic density (PSD) assembly, and may have a function in the signal-dependent recruitment and cross-linking of the other Shank paralogs |
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FMR1 and SHANK2 are central regulators of synaptic organization and function and genetic defects of these genes have effects on spine morphology and synaptic function |